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Toward a Therapy for Autism Spectrum Disorder: The Formyl Peptide Receptor 2 Agonist MR-39 Supports Synaptic Health in the BTBR Mouse and Features a Favorable Safety Profile.

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Title: Toward a Therapy for Autism Spectrum Disorder: The Formyl Peptide Receptor 2 Agonist MR-39 Supports Synaptic Health in the BTBR Mouse and Features a Favorable Safety Profile.
Authors: Vitone D; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy., Francavilla F; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy., Ferraro MG; Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy., Speranza L; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49 80131, Naples, Italy., Cristiano C; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49 80131, Naples, Italy., Arduino I; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy., Lopedota AA; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy., Rossignolo F; Aptuit Srl, an Evotec Company, Via A. Fleming, 4 37135, Verona, Italy., Fontana S; Aptuit Srl, an Evotec Company, Via A. Fleming, 4 37135, Verona, Italy., Lorenzin L; Department of Veterinary Medical Sciences (DIMEVET), and Interdepartmental Center for Industrial Research, Life Science and Health Technologies (CIRI-SdV), University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia (BO), Italy., Sannia M; Iret Foundation, Via Tolara di Sopra 41/E 40064, Ozzano Emilia (BO), Italy., Calzà L; Department of Pharmacy and Biotechnologies (FaBiT), and Health Technologies (CIRI-SdV), University of Bologna, Via Belmeloro 6 40126, Bologna, Italy., Denora N; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy., Volpicelli F; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49 80131, Naples, Italy., Crispino M; Department of Biology, University of Naples Federico II, Via Cinthia 80126, Naples, Italy., Lacivita E; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy., Leopoldo M; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.
Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2026 Jun 25; Vol. 9 (7), pp. 1911-1926. Date of Electronic Publication: 2026 Jun 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Vitone+D%22">Vitone D</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Francavilla+F%22">Francavilla F</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Ferraro+MG%22">Ferraro MG</searchLink>; Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Speranza+L%22">Speranza L</searchLink>; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cristiano+C%22">Cristiano C</searchLink>; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Arduino+I%22">Arduino I</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lopedota+AA%22">Lopedota AA</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Rossignolo+F%22">Rossignolo F</searchLink>; Aptuit Srl, an Evotec Company, Via A. Fleming, 4 37135, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Fontana+S%22">Fontana S</searchLink>; Aptuit Srl, an Evotec Company, Via A. Fleming, 4 37135, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Lorenzin+L%22">Lorenzin L</searchLink>; Department of Veterinary Medical Sciences (DIMEVET), and Interdepartmental Center for Industrial Research, Life Science and Health Technologies (CIRI-SdV), University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia (BO), Italy.<br /><searchLink fieldCode="AU" term="%22Sannia+M%22">Sannia M</searchLink>; Iret Foundation, Via Tolara di Sopra 41/E 40064, Ozzano Emilia (BO), Italy.<br /><searchLink fieldCode="AU" term="%22Calzà+L%22">Calzà L</searchLink>; Department of Pharmacy and Biotechnologies (FaBiT), and Health Technologies (CIRI-SdV), University of Bologna, Via Belmeloro 6 40126, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Denora+N%22">Denora N</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Volpicelli+F%22">Volpicelli F</searchLink>; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Crispino+M%22">Crispino M</searchLink>; Department of Biology, University of Naples Federico II, Via Cinthia 80126, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lacivita+E%22">Lacivita E</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Leopoldo+M%22">Leopoldo M</searchLink>; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, via Orabona 4 70125, Bari, Italy.
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