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Histidine, carnosine, and ergothioneine attenuate pyrazole/LPS-induced hepatotoxicity through modulation of CYP2E1, Nrf2, and NF-κB signaling in mice.

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Title: Histidine, carnosine, and ergothioneine attenuate pyrazole/LPS-induced hepatotoxicity through modulation of CYP2E1, Nrf2, and NF-κB signaling in mice.
Authors: Genç İ; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Karpuzoğlu FH; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey. handekarpuzoglu@yahoo.com.tr., Sözmen İ; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Kılınç S; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Aydın AF; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Bağbudar S; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey., Önder S; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey., Arslan AK; Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey., Abbasoğlu SD; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Uysal M; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.
Source: Molecular biology reports [Mol Biol Rep] 2026 Jul 15; Vol. 53 (1). Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1573-4978
DOI:10.1007/s11033-026-12341-5