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Histidine, carnosine, and ergothioneine attenuate pyrazole/LPS-induced hepatotoxicity through modulation of CYP2E1, Nrf2, and NF-κB signaling in mice.

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Title: Histidine, carnosine, and ergothioneine attenuate pyrazole/LPS-induced hepatotoxicity through modulation of CYP2E1, Nrf2, and NF-κB signaling in mice.
Authors: Genç İ; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Karpuzoğlu FH; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey. handekarpuzoglu@yahoo.com.tr., Sözmen İ; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Kılınç S; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Aydın AF; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Bağbudar S; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey., Önder S; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey., Arslan AK; Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey., Abbasoğlu SD; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey., Uysal M; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.
Source: Molecular biology reports [Mol Biol Rep] 2026 Jul 15; Vol. 53 (1). Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Histidine, carnosine, and ergothioneine attenuate pyrazole/LPS-induced hepatotoxicity through modulation of CYP2E1, Nrf2, and NF-κB signaling in mice.
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  Data: <searchLink fieldCode="AU" term="%22Genç+İ%22">Genç İ</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Karpuzoğlu+FH%22">Karpuzoğlu FH</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey. handekarpuzoglu@yahoo.com.tr.<br /><searchLink fieldCode="AU" term="%22Sözmen+İ%22">Sözmen İ</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Kılınç+S%22">Kılınç S</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Aydın+AF%22">Aydın AF</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Bağbudar+S%22">Bağbudar S</searchLink>; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Önder+S%22">Önder S</searchLink>; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Arslan+AK%22">Arslan AK</searchLink>; Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye, Turkey.<br /><searchLink fieldCode="AU" term="%22Abbasoğlu+SD%22">Abbasoğlu SD</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Uysal+M%22">Uysal M</searchLink>; Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Çapa, Fatih, Istanbul, Turkey.
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  Data: <searchLink fieldCode="JN" term="%220403234%22">Molecular biology reports</searchLink> [Mol Biol Rep] 2026 Jul 15; Vol. 53 (1). <i>Date of Electronic Publication: </i>2026 Jul 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Reidel%22">Reidel </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0403234 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-4978 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203014851%22">03014851 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biol Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11033-026-12341-5
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              Text: 2026 Jul 15
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