Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.
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| Title: | Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study. |
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| Authors: | Quan S; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Fu X; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Cai H; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Zhang W; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Geng Y; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Tian Q; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Ren Z; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Xu Y; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., An C; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Li J; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Wang W; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China. sunnywangwei@163.com.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. sunnywangwei@163.com., Jia L; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China. longfei@mail.ccmu.edu.cn.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. longfei@mail.ccmu.edu.cn. |
| Source: | Molecular biomedicine [Mol Biomed] 2026 Jul 15; Vol. 7 (1). Date of Electronic Publication: 2026 Jul 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2662-8651 |
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| DOI: | 10.1186/s43556-026-00513-5 |
