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Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.

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Title: Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.
Authors: Quan S; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Fu X; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Cai H; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Zhang W; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Geng Y; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Tian Q; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Ren Z; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Xu Y; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., An C; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Li J; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China., Wang W; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China. sunnywangwei@163.com.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. sunnywangwei@163.com., Jia L; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China. longfei@mail.ccmu.edu.cn.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. longfei@mail.ccmu.edu.cn.
Source: Molecular biomedicine [Mol Biomed] 2026 Jul 15; Vol. 7 (1). Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.
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  Data: <searchLink fieldCode="AU" term="%22Quan+S%22">Quan S</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+H%22">Cai H</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Geng+Y%22">Geng Y</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Tian+Q%22">Tian Q</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ren+Z%22">Ren Z</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22An+C%22">An C</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China. sunnywangwei@163.com.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. sunnywangwei@163.com.<br /><searchLink fieldCode="AU" term="%22Jia+L%22">Jia L</searchLink>; Department of Neurology and Innovation Center for Neurological Disorders, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, 45 Changchun St., Beijing, 100053, China. longfei@mail.ccmu.edu.cn.; Beijing Key Lab of Clinical Translational Research in Cognitive, Affective and Behavioral Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China. longfei@mail.ccmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918283581406676%22">Molecular biomedicine</searchLink> [Mol Biomed] 2026 Jul 15; Vol. 7 (1). <i>Date of Electronic Publication: </i>2026 Jul 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Singapore%22">Springer Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918283581406676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2662-8651 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226628651%22">26628651 </searchLink><i>NLM ISO Abbreviation: </i>Mol Biomed <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s43556-026-00513-5
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      – Code: eng
        Text: English
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      – TitleFull: Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.
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              Text: 2026 Jul 15
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