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Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.

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Title: Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.
Authors: Kelly ETR; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.; Centre de recherche en biologie structurale, McGill University, Montréal, QC H3G 0B1, Canada.; McGill Antimicrobial Resistance Center, Montréal, QC H4A 0B1, Canada., Myziuk I; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Hemmings MZ; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.; Centre de recherche en biologie structurale, McGill University, Montréal, QC H3G 0B1, Canada.; McGill Antimicrobial Resistance Center, Montréal, QC H4A 0B1, Canada., Mulla Z; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Blanchet J; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada., Ruzzini A; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada., Berghuis AM; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.; Centre de recherche en biologie structurale, McGill University, Montréal, QC H3G 0B1, Canada.; McGill Antimicrobial Resistance Center, Montréal, QC H4A 0B1, Canada.; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jul 21; Vol. 123 (29), pp. e2611077123. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.
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  Data: <searchLink fieldCode="AU" term="%22Kelly+ETR%22">Kelly ETR</searchLink>; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.; Centre de recherche en biologie structurale, McGill University, Montréal, QC H3G 0B1, Canada.; McGill Antimicrobial Resistance Center, Montréal, QC H4A 0B1, Canada.<br /><searchLink fieldCode="AU" term="%22Myziuk+I%22">Myziuk I</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.<br /><searchLink fieldCode="AU" term="%22Hemmings+MZ%22">Hemmings MZ</searchLink>; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.; Centre de recherche en biologie structurale, McGill University, Montréal, QC H3G 0B1, Canada.; McGill Antimicrobial Resistance Center, Montréal, QC H4A 0B1, Canada.<br /><searchLink fieldCode="AU" term="%22Mulla+Z%22">Mulla Z</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.<br /><searchLink fieldCode="AU" term="%22Blanchet+J%22">Blanchet J</searchLink>; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.<br /><searchLink fieldCode="AU" term="%22Ruzzini+A%22">Ruzzini A</searchLink>; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada.<br /><searchLink fieldCode="AU" term="%22Berghuis+AM%22">Berghuis AM</searchLink>; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.; Centre de recherche en biologie structurale, McGill University, Montréal, QC H3G 0B1, Canada.; McGill Antimicrobial Resistance Center, Montréal, QC H4A 0B1, Canada.; Department of Microbiology and Immunology, McGill University, Montréal, QC H3A 2B4, Canada.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jul 21; Vol. 123 (29), pp. e2611077123. <i>Date of Electronic Publication: </i>2026 Jul 15.
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              Text: 2026 Jul 21
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