Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.

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Title: Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.
Authors: Lange LM; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany. Electronic address: lara@gp2.org., Fang ZH; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Makarious MB; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kuznetsov N; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Atterling Brolin K; Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Ballard S; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Bardien S; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; South African Medical Research Council, Stellenbosch University Genomics of Brain Disorders Research Unit, Cape Town, South Africa., Doquenia ML; Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines; Department of Clinical Neurosciences, Mary Mediatrix Medical Center, Lipa, Batangas, Philippines; Department of Anatomy, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines., Heutink P; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA., Houlden H; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Iwaki H; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Jasaityte S; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Jones L; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Junker J; University Hospital Schleswig Holstein, Campus Lübeck, Lübeck, Germany; Center for Movement Disorders and Neuromodulation, University Hospital Düsseldorf, Düsseldorf, Germany., Kaiyrzhanov R; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK; Department of Neurology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan., Koretsky MJ; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Kumar KR; Neurology Department and Molecular Medicine Laboratory, Concord Repatriation General Hospital and University of Sydney, Concord, NSW, Australia; Translational Neurogenomics Group, Genomics and Inherited Disease Program, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Leonard HL; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Levine KS; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Lim SY; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Mencacci NE; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Mohamed WMY; Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Kuantan, Malaysia; Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, Shebin El-Kom, Menoufia, Egypt., Nalls MA; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Noyce AJ; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Ojha R; Department of Neurology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal., Okubadejo NU; Neurology Unit, Department of Medicine, College of Medicine, University of Lagos, Lagos State, Nigeria., Ur Rehman S; Department of Biotechnology, University of Science and Technology Bannu, Bannu, Pakistan., Screven L; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA., Shashkin C; International Research Institute of Postgraduate Education, Department of Neurosurgery and Neurology, Almaty, Kazakhstan; Shashkin Clinic, Almaty, Kazakhstan., Sopromadze S; Department of Neurology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia; East European University, Tbilisi, Georgia., Stafford EJ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Tan AH; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Tan M; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK; Department of Neurology, Oslo University Hospital, Oslo, Norway., Tavadyan Z; National Institute of Health, Yerevan, Armenia., Trinh J; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany., Tserensodnom B; Department of Neurology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Valente EM; Department of Molecular Medicine, University of Pavia, Pavia, Italy; Neurogenetics Research Center, IRCCS Mondino Foundation, Pavia, Italy., Vitale D; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Zharkinbekova N; Department of Neurology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan., Lohmann K; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany., Bandres-Ciga S; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Blauwendraat C; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA; Coalition for Aligning Science, Chevy Chase, MD, USA., Singleton AB; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA., Morris HR; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK; UCL Movement Disorders Centre, University College London, London, UK., Klein C; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany. Electronic address: christine.klein@uni-luebeck.de.
Corporate Authors: Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), Global Parkinson's Genetics Program (GP2)
Source: The Lancet. Neurology [Lancet Neurol] 2026 Aug; Vol. 25 (8), pp. 741-754.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.
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  Data: <searchLink fieldCode="AU" term="%22Lange+LM%22">Lange LM</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany. Electronic address: lara@gp2.org.<br /><searchLink fieldCode="AU" term="%22Fang+ZH%22">Fang ZH</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Makarious+MB%22">Makarious MB</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kuznetsov+N%22">Kuznetsov N</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Atterling+Brolin+K%22">Atterling Brolin K</searchLink>; Translational Neurogenetics Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ballard+S%22">Ballard S</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bardien+S%22">Bardien S</searchLink>; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; South African Medical Research Council, Stellenbosch University Genomics of Brain Disorders Research Unit, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Doquenia+ML%22">Doquenia ML</searchLink>; Department of Neuroscience and Brain Health, Metropolitan Medical Center, Manila, Philippines; Department of Clinical Neurosciences, Mary Mediatrix Medical Center, Lipa, Batangas, Philippines; Department of Anatomy, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines.<br /><searchLink fieldCode="AU" term="%22Heutink+P%22">Heutink P</searchLink>; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Houlden+H%22">Houlden H</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Iwaki+H%22">Iwaki H</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Jasaityte+S%22">Jasaityte S</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Jones+L%22">Jones L</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Junker+J%22">Junker J</searchLink>; University Hospital Schleswig Holstein, Campus Lübeck, Lübeck, Germany; Center for Movement Disorders and Neuromodulation, University Hospital Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kaiyrzhanov+R%22">Kaiyrzhanov R</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK; Department of Neurology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Koretsky+MJ%22">Koretsky MJ</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+KR%22">Kumar KR</searchLink>; Neurology Department and Molecular Medicine Laboratory, Concord Repatriation General Hospital and University of Sydney, Concord, NSW, Australia; Translational Neurogenomics Group, Genomics and Inherited Disease Program, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Leonard+HL%22">Leonard HL</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Levine+KS%22">Levine KS</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lim+SY%22">Lim SY</searchLink>; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Mencacci+NE%22">Mencacci NE</searchLink>; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mohamed+WMY%22">Mohamed WMY</searchLink>; Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Kuantan, Malaysia; Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, Shebin El-Kom, Menoufia, Egypt.<br /><searchLink fieldCode="AU" term="%22Nalls+MA%22">Nalls MA</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Noyce+AJ%22">Noyce AJ</searchLink>; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ojha+R%22">Ojha R</searchLink>; Department of Neurology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.<br /><searchLink fieldCode="AU" term="%22Okubadejo+NU%22">Okubadejo NU</searchLink>; Neurology Unit, Department of Medicine, College of Medicine, University of Lagos, Lagos State, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ur+Rehman+S%22">Ur Rehman S</searchLink>; Department of Biotechnology, University of Science and Technology Bannu, Bannu, Pakistan.<br /><searchLink fieldCode="AU" term="%22Screven+L%22">Screven L</searchLink>; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shashkin+C%22">Shashkin C</searchLink>; International Research Institute of Postgraduate Education, Department of Neurosurgery and Neurology, Almaty, Kazakhstan; Shashkin Clinic, Almaty, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Sopromadze+S%22">Sopromadze S</searchLink>; Department of Neurology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia; East European University, Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Stafford+EJ%22">Stafford EJ</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tan+AH%22">Tan AH</searchLink>; Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Tan+M%22">Tan M</searchLink>; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Tavadyan+Z%22">Tavadyan Z</searchLink>; National Institute of Health, Yerevan, Armenia.<br /><searchLink fieldCode="AU" term="%22Trinh+J%22">Trinh J</searchLink>; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Tserensodnom+B%22">Tserensodnom B</searchLink>; Department of Neurology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.<br /><searchLink fieldCode="AU" term="%22Valente+EM%22">Valente EM</searchLink>; Department of Molecular Medicine, University of Pavia, Pavia, Italy; Neurogenetics Research Center, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Vitale+D%22">Vitale D</searchLink>; DataTecnica, Washington, DC, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zharkinbekova+N%22">Zharkinbekova N</searchLink>; Department of Neurology, South Kazakhstan Medical Academy, Shymkent, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Lohmann+K%22">Lohmann K</searchLink>; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Bandres-Ciga+S%22">Bandres-Ciga S</searchLink>; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA; Coalition for Aligning Science, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Singleton+AB%22">Singleton AB</searchLink>; The Global Parkinson's Genetics Program (GP2), Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Morris+HR%22">Morris HR</searchLink>; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK; UCL Movement Disorders Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Institute of Neurogenetics, University of Luebeck, Lübeck, Germany. 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      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: 2026 Aug
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1474-4465
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: The Lancet. Neurology
              Type: main
ResultId 1