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Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.

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Title: Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.
Authors: Tang L; Medical School, Kunming University of Science and Technology, Kunming, PR China., Nie S; Medical School, Kunming University of Science and Technology, Kunming, PR China., Qi J; Yunnan Province Clinical Medical Center for Digestive System Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, PR China., Yu R; Medical School, Kunming University of Science and Technology, Kunming, PR China., Zhang J; Medical School, Kunming University of Science and Technology, Kunming, PR China., Zhu R; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, PR China., Li Q; Medical School, Kunming University of Science and Technology, Kunming, PR China., Zhou X; Medical School, Kunming University of Science and Technology, Kunming, PR China., Dai S; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, PR China., Wang L; Department of Pathology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, PR China., Chen M; Yunnan Key Laboratory of Cell Metabolism and Diseases, Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, PR China., Yang F; Medical School, Kunming University of Science and Technology, Kunming, PR China., Zhang J; Medical School, Kunming University of Science and Technology, Kunming, PR China. zhjihong2000@kust.edu.cn.; Yunnan Province Clinical Medical Center for Digestive System Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, PR China. zhjihong2000@kust.edu.cn.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jul 15. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting POLRMT-driven epigenetic remodeling of Wnt/β-catenin to eradicate colorectal cancer stem cell proliferation.
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  Data: <searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Nie+S%22">Nie S</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Yunnan Province Clinical Medical Center for Digestive System Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Yu+R%22">Yu R</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Zhu+R%22">Zhu R</searchLink>; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Dai+S%22">Dai S</searchLink>; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Pathology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Yunnan Key Laboratory of Cell Metabolism and Diseases, Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Medical School, Kunming University of Science and Technology, Kunming, PR China. zhjihong2000@kust.edu.cn.; Yunnan Province Clinical Medical Center for Digestive System Diseases, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, PR China. zhjihong2000@kust.edu.cn.
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        Value: 10.1038/s41418-026-01807-5
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              Text: 2026 Jul 15
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