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PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome.

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Title: PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome.
Authors: Christiaenssen B; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium., Mortelmans S; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium., Baghli S; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium., Boone F; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Xie W; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Bertoni A; UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Ha M; Antwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium., Ogunjimi B; Antwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium.; Department of Paediatrics, Antwerp University Hospital, Antwerp, Belgium., Sabato V; Department of Immunology, Allergology, and Rheumatology, Antwerp University Hospital, Edegem, Belgium.; Department of Immunology, Allergology, and Rheumatology, University of Antwerp, Wilrijk, Belgium., Gattorno M; UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Vandenabeele P; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., van Loo G; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Hoste E; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Wullaert A; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. andy.wullaert@uantwerpen.be.; VIB Center for Inflammation Research, VIB, Ghent, Belgium. andy.wullaert@uantwerpen.be.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. andy.wullaert@uantwerpen.be.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jul 15. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Christiaenssen+B%22">Christiaenssen B</searchLink>; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Mortelmans+S%22">Mortelmans S</searchLink>; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Baghli+S%22">Baghli S</searchLink>; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Boone+F%22">Boone F</searchLink>; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Xie+W%22">Xie W</searchLink>; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Bertoni+A%22">Bertoni A</searchLink>; UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Ha+M%22">Ha M</searchLink>; Antwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Ogunjimi+B%22">Ogunjimi B</searchLink>; Antwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium.; Department of Paediatrics, Antwerp University Hospital, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Sabato+V%22">Sabato V</searchLink>; Department of Immunology, Allergology, and Rheumatology, Antwerp University Hospital, Edegem, Belgium.; Department of Immunology, Allergology, and Rheumatology, University of Antwerp, Wilrijk, Belgium.<br /><searchLink fieldCode="AU" term="%22Gattorno+M%22">Gattorno M</searchLink>; UOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Vandenabeele+P%22">Vandenabeele P</searchLink>; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22van+Loo+G%22">van Loo G</searchLink>; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Hoste+E%22">Hoste E</searchLink>; VIB Center for Inflammation Research, VIB, Ghent, Belgium.; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Wullaert+A%22">Wullaert A</searchLink>; Cell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. andy.wullaert@uantwerpen.be.; VIB Center for Inflammation Research, VIB, Ghent, Belgium. andy.wullaert@uantwerpen.be.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. andy.wullaert@uantwerpen.be.
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