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An encyclopedia of human enhancer-gene regulatory interactions.

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Title: An encyclopedia of human enhancer-gene regulatory interactions.
Authors: Gschwind AR; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Mualim KS; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Plant Biology, Carnegie Institute of Science, Stanford, CA, USA., Karbalayghareh A; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sheth MU; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA.; Department of Bioengineering, Stanford University, Stanford, CA, USA., Dey KK; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Jagoda E; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nurtdinov RN; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Xi W; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tan AS; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Galante J; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Jones H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Ma XR; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Yao D; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Amgalan D; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Ray J; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Munger CJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Nasser J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Avsec Ž; Google DeepMind, London, UK., James BT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Shamim MS; Department of Pathology, Mass General Brigham, Boston, MA, USA., Durand NC; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rao SSP; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Structural Biology, Stanford University, Stanford, CA, USA.; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Mahajan R; Center for Theoretical Biological Physics, Rice University, Houston, TX, USA.; Department of Biosciences, Rice University, Houston, TX, USA., Doughty BR; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Andreeva K; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Ulirsch JC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Artificial Intelligence Laboratory, Illumina Inc., San Diego, CA, USA., Fan K; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Perez EM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen TC; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA., Kelley DR; Calico Life Sciences LLC, South San Francisco, CA, USA., Finucane HK; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Moore JE; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Weng Z; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Bassik MC; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Ustun B; Halıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA, USA.; Department of Computer Science and Engineering, University of California San Diego, San Diego, CA, USA., Price AL; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Beer MA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Guigó R; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Stamatoyannopoulos JA; Altius Institute for Biomedical Sciences, Seattle, WA, USA.; Clinical Research Division, Fred Hutch Cancer Center, Seattle, WA, USA., Lieberman Aiden E; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.; Center for Theoretical Biological Physics, Rice University, Houston, TX, USA.; Department of Biosciences, Rice University, Houston, TX, USA., Greenleaf WJ; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Applied Physics, Stanford University, Stanford, CA, USA., Leslie CS; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Steinmetz LM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Genome Technology Center, Palo Alto, CA, USA.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Kundaje A; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA., Engreitz JM; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. engreitz@stanford.edu.; Basic Sciences and Engineering Initiative, Betty Irene Moore Children's Heart Center, Lucile Packard Children's Hospital, Stanford, CA, USA. engreitz@stanford.edu.; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. engreitz@stanford.edu.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. engreitz@stanford.edu.
Source: Nature [Nature] 2026 Jul 15. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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