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ESCRT-III assembles around mis-segregated DNA to protect genome stability.

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Title: ESCRT-III assembles around mis-segregated DNA to protect genome stability.
Authors: Glover J; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK., Talledge N; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA., McCullough J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Alian A; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Sadler JBA; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK., Kamboj S; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK., Dempsey NWM; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA., Laughlin TG; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Nguyen HC; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA., Wenzel DM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Lalonde MS; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Paine EL; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Ganser-Pornillos B; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Ventimiglia LN; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK., LaJoie D; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Iwasa JH; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Arthur CP; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Lee DJ; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Moss FR 3rd; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Venkatesh M; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA., Arnold LM; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA., Johnson JS; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA., Ullman KS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Frost A; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA. afrost@altoslabs.com.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. afrost@altoslabs.com.; Chan Zuckerberg Biohub, San Francisco, CA, USA. afrost@altoslabs.com.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. afrost@altoslabs.com.; Quantitative Biosciences Institute, University of California, San Francisco, CA, USA. afrost@altoslabs.com., Sundquist WI; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. wes@biochem.utah.edu., Martin-Serrano J; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK. juan.martin_serrano@kcl.ac.uk.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 Jul 15. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Glover+J%22">Glover J</searchLink>; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Talledge+N%22">Talledge N</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22McCullough+J%22">McCullough J</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Alian+A%22">Alian A</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Sadler+JBA%22">Sadler JBA</searchLink>; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kamboj+S%22">Kamboj S</searchLink>; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Dempsey+NWM%22">Dempsey NWM</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Laughlin+TG%22">Laughlin TG</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+HC%22">Nguyen HC</searchLink>; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wenzel+DM%22">Wenzel DM</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Lalonde+MS%22">Lalonde MS</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Paine+EL%22">Paine EL</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Ganser-Pornillos+B%22">Ganser-Pornillos B</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Ventimiglia+LN%22">Ventimiglia LN</searchLink>; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22LaJoie+D%22">LaJoie D</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Iwasa+JH%22">Iwasa JH</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Arthur+CP%22">Arthur CP</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+DJ%22">Lee DJ</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Moss+FR+3rd%22">Moss FR 3rd</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Venkatesh+M%22">Venkatesh M</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Arnold+LM%22">Arnold LM</searchLink>; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+JS%22">Johnson JS</searchLink>; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Ullman+KS%22">Ullman KS</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Frost+A%22">Frost A</searchLink>; Altos Labs, Bay Area Institute of Science, Redwood City, CA, USA. afrost@altoslabs.com.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. afrost@altoslabs.com.; Chan Zuckerberg Biohub, San Francisco, CA, USA. afrost@altoslabs.com.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. afrost@altoslabs.com.; Quantitative Biosciences Institute, University of California, San Francisco, CA, USA. afrost@altoslabs.com.<br /><searchLink fieldCode="AU" term="%22Sundquist+WI%22">Sundquist WI</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. wes@biochem.utah.edu.<br /><searchLink fieldCode="AU" term="%22Martin-Serrano+J%22">Martin-Serrano J</searchLink>; Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK. juan.martin_serrano@kcl.ac.uk.
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