Comparative Evaluation of Rituximab Versus Approved Therapies in Aquaporin-4-IgG-Positive Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Network Meta-analysis.

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Title: Comparative Evaluation of Rituximab Versus Approved Therapies in Aquaporin-4-IgG-Positive Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Network Meta-analysis.
Authors: Barzegar M; Department of Neurology, Toledo University, Toledo, OH, USA., Samadzadeh S; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Institute of Regional Health Research & Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Slagelse Hospitals, Slagelse, Denmark., Audoin B; APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France.; Department of Neurology, University Hospital of Marseille, Aix-Marseille University, CNRS, CRMBM, Marseille, France., Berthele A; Department of Neurology, School of Medicine and Health, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany., Altintas A; Neurology Department, School of Medicine, Koç University, Istanbul, Turkey.; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey., Willekens B; Department of Neurology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.; Translational Sciences Research Group, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Laboratory of Experimental Haematology, VAXINFECTIO, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Laakso S; Neurocenter, Helsinki University Hospital, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Jahani S; Institute of Regional Health Research & Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Slagelse Hospitals, Slagelse, Denmark., Papp V; Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital-Rigshospitalet, 2600, Glostrup, Denmark., Zappe C; Department of Neurology, School of Medicine and Health, Technical University Munich, Klinikum Rechts der Isar, Munich, Germany., Lefter A; Department of Neurology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.; Translational Sciences Research Group, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Siva A; Department of Neurology, Istanbul University-Cerrahpaşa Faculty of Medicine, Istanbul, Turkey., Afshari-Safavi A; Institute of Regional Health Research & Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Neurology, Slagelse Hospitals, Slagelse, Denmark., Möller S; Open Patient Data Explorative Network, Odense University Hospital, University of Southern Denmark, Odense, Denmark., Wokke B; Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Cortese R; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy., Illes Z; Department of Neurology, Odense University Hospital, Odense, Denmark., Huda S; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK., Paulus R; Department of Neurology, Medical University of Vienna, Vienna, Austria., Messina S; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Collongues N; Department of Neurology, University Hospital of Strasbourg, Strasbourg, France.; Department of Pharmacology, Addictology, Toxicology, and Therapeutics, Strasbourg University, Strasbourg, France., Ringelstein M; Department of Neurology, University Clinic and Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Cobo-Calvo Á; Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Hacohen Y; Department of Neurology, Great Ormond Street Hospital for Children, London, UK.; Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, UK., Arrambide G; Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Palace J; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Mariotto S; Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy., Marignier R; Hospices Civils de Lyon, Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-Inflammation, Hôpital Neurologique Pierre Wertheimer, Bron Cedex, France., Geraldes R; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Paul F; Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Neuroscience Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Asgari N; Institute of Regional Health Research & Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. nasgari@health.sdu.dk.; Department of Neurology, Slagelse Hospitals, Slagelse, Denmark. nasgari@health.sdu.dk.; Department of Regional Health Research & Molecular Medicine, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark. nasgari@health.sdu.dk.
Corporate Authors: MEDEN study group
Source: Neurology and therapy [Neurol Ther] 2026 Jul 16. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Country of Publication: New Zealand NLM ID: 101637818 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2193-8253 (Print) Linking ISSN: 21936536 NLM ISO Abbreviation: Neurol Ther
Database: MEDLINE Ultimate
Description
ISSN:2193-8253
DOI:10.1007/s40120-026-00989-x