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ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice.

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Title: ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice.
Authors: Thomas NT; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA., Brightwell CR; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA., Carter T; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA., Keeble AR; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA., Gonzalez-Velez S; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA., Latham CM; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA., Owen AM; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA., Wen Y; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA., Murach KA; Exercise Science Research Center, Department of Health, University of Arkansas, Human Performance, and Recreation, Fayetteville, AR, USA.; Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR, USA., Fry CS; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA. cfr223@uky.edu.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA. cfr223@uky.edu.
Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2026 Jul 15. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-3658 (Electronic) Linking ISSN: 10761551 NLM ISO Abbreviation: Mol Med Subsets: MEDLINE
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  Data: ACL injury reprograms quadriceps myonuclear epigenetic and transcriptional signatures in mice.
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  Data: <searchLink fieldCode="AU" term="%22Thomas+NT%22">Thomas NT</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Brightwell+CR%22">Brightwell CR</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Carter+T%22">Carter T</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.<br /><searchLink fieldCode="AU" term="%22Keeble+AR%22">Keeble AR</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Velez+S%22">Gonzalez-Velez S</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Latham+CM%22">Latham CM</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Owen+AM%22">Owen AM</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Wen+Y%22">Wen Y</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA.; Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.; Division of Biomedical Informatics, Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA.<br /><searchLink fieldCode="AU" term="%22Murach+KA%22">Murach KA</searchLink>; Exercise Science Research Center, Department of Health, University of Arkansas, Human Performance, and Recreation, Fayetteville, AR, USA.; Cell and Molecular Biology Graduate Program, University of Arkansas, Fayetteville, AR, USA.<br /><searchLink fieldCode="AU" term="%22Fry+CS%22">Fry CS</searchLink>; Center for Muscle Biology, University of Kentucky, 900 S. Limestone Street, CTW 210A, Lexington, KY, 40536-0200, USA. cfr223@uky.edu.; Department of Athletic Training and Clinical Nutrition, College of Health Sciences, University of Kentucky, Lexington, Kentucky, 40536, USA. cfr223@uky.edu.
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              Text: 2026 Jul 15
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