Elevated on-treatment D-dimer level is associated with major bleeding during extended anticoagulation for venous thromboembolism.

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Title: Elevated on-treatment D-dimer level is associated with major bleeding during extended anticoagulation for venous thromboembolism.
Authors: Wang H; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa., Kovacs MJ; Department of Medicine, Western University, London, Ontario., Lazo-Langner A; Department of Medicine, Western University, London, Ontario., Anderson DR; Department of Medicine, Dalhousie University, Halifax., Kahn SR; Department of Medicine, McGill University, Montreal., Castellucci LA; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa., Schmidt J; Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont., Elias A; Centre Hospitalier Intercommunal Toulon La Seyne-sur-Mer, Toulon., Righini M; Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva., Ortel TL; Department of Medicine, Duke University, Durham, North Carolina., Huisman MV; Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden., Carrier M; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa., Mallick R; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa., Rodger MA; Department of Medicine, McGill University, Montreal., Le Gal G; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa., Wells PS; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa., Xu Y; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa. yaxu@toh.ca.
Source: Haematologica [Haematologica] 2026 Jul 16. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Elevated on-treatment D-dimer level is associated with major bleeding during extended anticoagulation for venous thromboembolism.
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  Data: <searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa.<br /><searchLink fieldCode="AU" term="%22Kovacs+MJ%22">Kovacs MJ</searchLink>; Department of Medicine, Western University, London, Ontario.<br /><searchLink fieldCode="AU" term="%22Lazo-Langner+A%22">Lazo-Langner A</searchLink>; Department of Medicine, Western University, London, Ontario.<br /><searchLink fieldCode="AU" term="%22Anderson+DR%22">Anderson DR</searchLink>; Department of Medicine, Dalhousie University, Halifax.<br /><searchLink fieldCode="AU" term="%22Kahn+SR%22">Kahn SR</searchLink>; Department of Medicine, McGill University, Montreal.<br /><searchLink fieldCode="AU" term="%22Castellucci+LA%22">Castellucci LA</searchLink>; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa.<br /><searchLink fieldCode="AU" term="%22Schmidt+J%22">Schmidt J</searchLink>; Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont.<br /><searchLink fieldCode="AU" term="%22Elias+A%22">Elias A</searchLink>; Centre Hospitalier Intercommunal Toulon La Seyne-sur-Mer, Toulon.<br /><searchLink fieldCode="AU" term="%22Righini+M%22">Righini M</searchLink>; Division of Angiology and Hemostasis, Geneva University Hospitals and Faculty of Medicine, Geneva.<br /><searchLink fieldCode="AU" term="%22Ortel+TL%22">Ortel TL</searchLink>; Department of Medicine, Duke University, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Huisman+MV%22">Huisman MV</searchLink>; Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden.<br /><searchLink fieldCode="AU" term="%22Carrier+M%22">Carrier M</searchLink>; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa.<br /><searchLink fieldCode="AU" term="%22Mallick+R%22">Mallick R</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada; Ottawa Methods Centre, Ottawa Hospital Research Institute, Ottawa.<br /><searchLink fieldCode="AU" term="%22Rodger+MA%22">Rodger MA</searchLink>; Department of Medicine, McGill University, Montreal.<br /><searchLink fieldCode="AU" term="%22Le+Gal+G%22">Le Gal G</searchLink>; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa.<br /><searchLink fieldCode="AU" term="%22Wells+PS%22">Wells PS</searchLink>; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Medicine, University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Canada; School of Epidemiology and Public Health, University of Ottawa, Ottawa. yaxu@toh.ca.
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        Value: 10.3324/haematol.2026.300589
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              Text: 2026 Jul 16
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