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Extracellular vesicles as prognostic biomarkers: results of a neoadjuvant chemoimmunotherapy clinical trial in stage IIIA (N2) non-small-cell lung cancer (SAKK 16/14).

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Title: Extracellular vesicles as prognostic biomarkers: results of a neoadjuvant chemoimmunotherapy clinical trial in stage IIIA (N2) non-small-cell lung cancer (SAKK 16/14).
Authors: da Silva Y; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland., Chiang DM; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Animal Physiology and Immunology, Technical University of Munich (TUM) School of Life Sciences, Technical University of Munich, Freising, Germany., Benecke L; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland., Pfaffl MW; Department of Animal Physiology and Immunology, Technical University of Munich (TUM) School of Life Sciences, Technical University of Munich, Freising, Germany., Hayoz S; Swiss Cancer Institute (SAKK) Competence Center, Bern, Switzerland., Chiquet S; Swiss Cancer Institute (SAKK) Competence Center, Bern, Switzerland., Prince SS; Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Bettini A; Department of Oncology, Hôpital Fribourgeois (HFR) Fribourg - Hôpital Fribourgeois, Fribourg, Switzerland., Früh M; Department of Oncology/Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.; Department of Oncology, Inselspital Bern, Bern, Switzerland., Mauti LA; Department of Oncology/Hematology, Cantonal Hospital Winterthur, Winterthur, Switzerland., Britschgi C; Department of Oncology/Hematology, Cantonal Hospital Winterthur, Winterthur, Switzerland.; Department of Medical Oncology and Hematology, Comprehensive Cancer Center Zurich, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Peters S; Department of Oncology, University Hospital Lausanne Centre hospitalier universitaire vadois (CHUV), Lausanne, Switzerland., Mark M; Divison of Oncology/Hematology, Cantonal Hospital Graubünden, Chur, Switzerland., Ochsenbein AF; Department of Oncology, Inselspital Bern, Bern, Switzerland., Janthur WD; Department of Oncology/Hematology, Cantonal Hospital Aarau, Aarau, Switzerland., Waibel C; Department of Oncology/Hematology, Cantonal Hospital Baden, Baden, Switzerland., Mach N; Department of Oncology, University Hospital Geneva, Geneva, Switzerland., Froesch P; Oncology Institute of Southern Switzerland, Locarno, Switzerland., Buess M; Division of Medical Oncology, St. Claraspital, Basel, Switzerland., Bohanes P; Centre de Chimiothérapie Anti-Cancéreuse, Lausanne, Switzerland., Gonzalez M; Department of Thoracic Surgery, University Hospital Lausanne Centre hospitalier universitaire vadois (CHUV), Lausanne, Switzerland., Zippelius A; Department Medical Oncology, University Hospital Basel, Basel, Switzerland., Pless M; Swiss Cancer Institute (SAKK) Competence Center, Bern, Switzerland.; Department of Oncology/Hematology, Cantonal Hospital Winterthur, Winterthur, Switzerland., Rothschild SI; Department of Oncology/Hematology, Cantonal Hospital Baden, Baden, Switzerland.; Department Medical Oncology, University Hospital Basel, Basel, Switzerland., Muller L; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland.
Source: Frontiers in immunology [Front Immunol] 2026 Jul 01; Vol. 17, pp. 1807542. Date of Electronic Publication: 2026 Jul 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Extracellular vesicles as prognostic biomarkers: results of a neoadjuvant chemoimmunotherapy clinical trial in stage IIIA (N2) non-small-cell lung cancer (SAKK 16/14).
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  Data: <searchLink fieldCode="AU" term="%22da+Silva+Y%22">da Silva Y</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chiang+DM%22">Chiang DM</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Animal Physiology and Immunology, Technical University of Munich (TUM) School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Benecke+L%22">Benecke L</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pfaffl+MW%22">Pfaffl MW</searchLink>; Department of Animal Physiology and Immunology, Technical University of Munich (TUM) School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Hayoz+S%22">Hayoz S</searchLink>; Swiss Cancer Institute (SAKK) Competence Center, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chiquet+S%22">Chiquet S</searchLink>; Swiss Cancer Institute (SAKK) Competence Center, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Prince+SS%22">Prince SS</searchLink>; Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bettini+A%22">Bettini A</searchLink>; Department of Oncology, Hôpital Fribourgeois (HFR) Fribourg - Hôpital Fribourgeois, Fribourg, Switzerland.<br /><searchLink fieldCode="AU" term="%22Früh+M%22">Früh M</searchLink>; Department of Oncology/Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.; Department of Oncology, Inselspital Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mauti+LA%22">Mauti LA</searchLink>; Department of Oncology/Hematology, Cantonal Hospital Winterthur, Winterthur, Switzerland.<br /><searchLink fieldCode="AU" term="%22Britschgi+C%22">Britschgi C</searchLink>; Department of Oncology/Hematology, Cantonal Hospital Winterthur, Winterthur, Switzerland.; Department of Medical Oncology and Hematology, Comprehensive Cancer Center Zurich, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Peters+S%22">Peters S</searchLink>; Department of Oncology, University Hospital Lausanne Centre hospitalier universitaire vadois (CHUV), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mark+M%22">Mark M</searchLink>; Divison of Oncology/Hematology, Cantonal Hospital Graubünden, Chur, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ochsenbein+AF%22">Ochsenbein AF</searchLink>; Department of Oncology, Inselspital Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Janthur+WD%22">Janthur WD</searchLink>; Department of Oncology/Hematology, Cantonal Hospital Aarau, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Waibel+C%22">Waibel C</searchLink>; Department of Oncology/Hematology, Cantonal Hospital Baden, Baden, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mach+N%22">Mach N</searchLink>; Department of Oncology, University Hospital Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Froesch+P%22">Froesch P</searchLink>; Oncology Institute of Southern Switzerland, Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Buess+M%22">Buess M</searchLink>; Division of Medical Oncology, St. Claraspital, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bohanes+P%22">Bohanes P</searchLink>; Centre de Chimiothérapie Anti-Cancéreuse, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gonzalez+M%22">Gonzalez M</searchLink>; Department of Thoracic Surgery, University Hospital Lausanne Centre hospitalier universitaire vadois (CHUV), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zippelius+A%22">Zippelius A</searchLink>; Department Medical Oncology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pless+M%22">Pless M</searchLink>; Swiss Cancer Institute (SAKK) Competence Center, Bern, Switzerland.; Department of Oncology/Hematology, Cantonal Hospital Winterthur, Winterthur, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rothschild+SI%22">Rothschild SI</searchLink>; Department of Oncology/Hematology, Cantonal Hospital Baden, Baden, Switzerland.; Department Medical Oncology, University Hospital Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Muller+L%22">Muller L</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland.; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Basel, Basel, Switzerland.
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