Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: Study Protocol of the International AnTi-FREEZE Study.

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Title: Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: Study Protocol of the International AnTi-FREEZE Study.
Authors: Goossens FM; Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Ehgoetz Martens KA; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada., Bloem BR; Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Helmich RC; Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Howe EE; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada., Kessels RPC; Donders Centre of Cognition, Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, the Netherlands.; Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands.; Klimmendaal Rehabilitation Specialists, Arnhem, the Netherlands.; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands., Roerdink M; Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.; Department of Nutrition and Movement Sciences, NUTRIM Institute of Nutrition and Translational Research in Metabolism & MHeNs Institute of Mental Health and Neurosciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands., Bryant AG; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia., Shine JM; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia., Tosserams A; Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands., Lewis SJG; Parkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, New South Wales, Australia., Nonnekes J; Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Source: The European journal of neuroscience [Eur J Neurosci] 2026 Jul; Vol. 64 (2), pp. e70630.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
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  Data: Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: Study Protocol of the International AnTi-FREEZE Study.
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  Data: <searchLink fieldCode="AU" term="%22Goossens+FM%22">Goossens FM</searchLink>; Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ehgoetz+Martens+KA%22">Ehgoetz Martens KA</searchLink>; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bloem+BR%22">Bloem BR</searchLink>; Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Helmich+RC%22">Helmich RC</searchLink>; Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Howe+EE%22">Howe EE</searchLink>; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kessels+RPC%22">Kessels RPC</searchLink>; Donders Centre of Cognition, Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, the Netherlands.; Vincent van Gogh Institute for Psychiatry, Venray, the Netherlands.; Klimmendaal Rehabilitation Specialists, Arnhem, the Netherlands.; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Roerdink+M%22">Roerdink M</searchLink>; Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.; Department of Nutrition and Movement Sciences, NUTRIM Institute of Nutrition and Translational Research in Metabolism & MHeNs Institute of Mental Health and Neurosciences, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bryant+AG%22">Bryant AG</searchLink>; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Shine+JM%22">Shine JM</searchLink>; Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Tosserams+A%22">Tosserams A</searchLink>; Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Neurology, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lewis+SJG%22">Lewis SJG</searchLink>; Parkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Nonnekes+J%22">Nonnekes J</searchLink>; Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
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              Text: 2026 Jul
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