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Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy.

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Title: Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy.
Authors: Deng Z; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. zhiqiangdeng@hkbu.edu.hk.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China. zhiqiangdeng@hkbu.edu.hk., Kan Y; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Liu J; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Ying KY; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Yang Y; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Guan X; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Xu X; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Su C; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China., Lu J; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Lu K; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Chen Y; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Krishnamoorthi S; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Lu JH; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China., Iyaswamy A; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Cheung KH; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China., Song JX; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Yue Z; Departments of Neurology and Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhenyu.yue@mssm.edu., Li M; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. limin@hkbu.edu.hk.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China. limin@hkbu.edu.hk.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jul 16. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy.
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  Data: <searchLink fieldCode="AU" term="%22Deng+Z%22">Deng Z</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. zhiqiangdeng@hkbu.edu.hk.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China. zhiqiangdeng@hkbu.edu.hk.<br /><searchLink fieldCode="AU" term="%22Kan+Y%22">Kan Y</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Ying+KY%22">Ying KY</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; 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Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Krishnamoorthi+S%22">Krishnamoorthi S</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Lu+JH%22">Lu JH</searchLink>; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Iyaswamy+A%22">Iyaswamy A</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Cheung+KH%22">Cheung KH</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Song+JX%22">Song JX</searchLink>; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Yue+Z%22">Yue Z</searchLink>; Departments of Neurology and Neuroscience, The Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhenyu.yue@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research (CPDR), Golden Meditech Centre for NeuroRegeneration Science (GCNS), HKBU Musketeers Foundation Traditional Chinese Medicine Research Institute for Age-related Diseases (MFRI), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. limin@hkbu.edu.hk.; Institute for Research and Continuing Education, Hong Kong Baptist University, Shenzhen, China. limin@hkbu.edu.hk.
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      – TitleFull: Schizophrenia and bipolar disorder risk gene AKAP11 sustains cognitive function by regulating TFEB-mediated autophagy.
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              Text: 2026 Jul 16
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              Y: 2026
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