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Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.

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Title: Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.
Authors: Mu WC; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA., Barthez M; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA., Feng Y; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA., Chen Y; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA., Wang CL; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA., Huang JY; Buck Institute for Research on Aging, Novato, CA, USA.; Gladstone Institutes and University of California, San Francisco, CA, USA., Li J; Bioinformatics Core, University of California, Davis, CA, USA., Lanhart P; Active Motif, Carlsbad, CA, USA., Tsui C; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA., Kim YJ; Chan Zuckerberg Biohub, San Francisco, CA, USA., Verdin E; Buck Institute for Research on Aging, Novato, CA, USA.; Gladstone Institutes and University of California, San Francisco, CA, USA., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. mihai.netea@radboudumc.nl.; Department of Immunology and Metabolism, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. mihai.netea@radboudumc.nl., Chen D; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA. danicac@berkeley.edu.
Source: Nature aging [Nat Aging] 2026 Jul 16. Date of Electronic Publication: 2026 Jul 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mu+WC%22">Mu WC</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barthez+M%22">Barthez M</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+CL%22">Wang CL</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+JY%22">Huang JY</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Gladstone Institutes and University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Bioinformatics Core, University of California, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lanhart+P%22">Lanhart P</searchLink>; Active Motif, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tsui+C%22">Tsui C</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+YJ%22">Kim YJ</searchLink>; Chan Zuckerberg Biohub, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Verdin+E%22">Verdin E</searchLink>; Buck Institute for Research on Aging, Novato, CA, USA.; Gladstone Institutes and University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Netea+MG%22">Netea MG</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. mihai.netea@radboudumc.nl.; Department of Immunology and Metabolism, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. mihai.netea@radboudumc.nl.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Metabolic Biology and Nutrition, University of California, Berkeley, CA, USA. danicac@berkeley.edu.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Jul 16. <i>Date of Electronic Publication: </i>2026 Jul 16.
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        Value: 10.1038/s43587-026-01175-2
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              Text: 2026 Jul 16
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