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Targeting the CAF-GDF15 axis attenuates AKT-mediated mitochondrial rewiring and chemoradiation resistance in esophageal adenocarcinoma.

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Title: Targeting the CAF-GDF15 axis attenuates AKT-mediated mitochondrial rewiring and chemoradiation resistance in esophageal adenocarcinoma.
Authors: Fan N; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.; Department of Thoracic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China., Deng P; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Wang Z; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Ju F; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Raatz L; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Camacho OV; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany., Hillmer AM; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, 50931, Germany., Odenthal M; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany., Nguyen PH; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, Cologne, 50931, Germany., Lyu Z; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Popp F; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Chon SH; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany., Bijlsma MF; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, RDC Adore, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands., Ros R; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, RDC Adore, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands., van Laarhoven HWM; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.; Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Quaas A; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany., Wischhusen J; Department for Obstetrics & Gynaecology, University Hospital Würzburg, Section for Experimental Tumor Immunology, Josef-Schneider-Str. 4, Würzburg, 97080, Germany., Zhao Y; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany. yue.zhao@uk-koeln.de., Bruns CJ; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany. christiane.bruns@uk-koeln.de.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, 50931, Germany. christiane.bruns@uk-koeln.de.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Jul 17; Vol. 45 (1). Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting the CAF-GDF15 axis attenuates AKT-mediated mitochondrial rewiring and chemoradiation resistance in esophageal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Fan+N%22">Fan N</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.; Department of Thoracic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.<br /><searchLink fieldCode="AU" term="%22Deng+P%22">Deng P</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Ju+F%22">Ju F</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Raatz+L%22">Raatz L</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Camacho+OV%22">Camacho OV</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Hillmer+AM%22">Hillmer AM</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Odenthal+M%22">Odenthal M</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Nguyen+PH%22">Nguyen PH</searchLink>; Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, Cologne, 50931, Germany.<br /><searchLink fieldCode="AU" term="%22Lyu+Z%22">Lyu Z</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Popp+F%22">Popp F</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Chon+SH%22">Chon SH</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Bijlsma+MF%22">Bijlsma MF</searchLink>; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, RDC Adore, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ros+R%22">Ros R</searchLink>; Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, RDC Adore, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Laarhoven+HWM%22">van Laarhoven HWM</searchLink>; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.; Department of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Quaas+A%22">Quaas A</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, 50937, Germany.<br /><searchLink fieldCode="AU" term="%22Wischhusen+J%22">Wischhusen J</searchLink>; Department for Obstetrics & Gynaecology, University Hospital Würzburg, Section for Experimental Tumor Immunology, Josef-Schneider-Str. 4, Würzburg, 97080, Germany.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany. yue.zhao@uk-koeln.de.<br /><searchLink fieldCode="AU" term="%22Bruns+CJ%22">Bruns CJ</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, 50937, Germany. christiane.bruns@uk-koeln.de.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, 50931, Germany. christiane.bruns@uk-koeln.de.
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  Data: <searchLink fieldCode="JN" term="%228308647%22">Journal of experimental & clinical cancer research : CR</searchLink> [J Exp Clin Cancer Res] 2026 Jul 17; Vol. 45 (1). <i>Date of Electronic Publication: </i>2026 Jul 17.
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        Value: 10.1186/s13046-026-03776-6
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              Text: 2026 Jul 17
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