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Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV.

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Title: Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV.
Authors: Giron LB; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Shaikh MW; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA., Cantu Jungles TM; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN 47907, USA., Zhang L; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA., Engen PA; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA., Bulut N; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN 47907, USA., Singh S; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Hasson JM; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Zhang E; Department of Cell and Developmental Biology, Northwestern University, Chicago, IL 60611, USA., Shankaran S; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Neumann C; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA., Villanueva M; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA., Landay AL; Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA., Hope TJ; Department of Cell and Developmental Biology, Northwestern University, Chicago, IL 60611, USA., Palella FJ; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Corley MJ; University of California San Diego, La Jolla, CA 92093, USA., Tateno H; Cellular and Molecular Biotechnology Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan., Hamaker B; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN 47907, USA., Auslander N; The Wistar Institute, Philadelphia, PA 19104, USA., Redondo RL; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Keshavarzian A; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA., Abdel-Mohsen M; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 10. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV.
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  Data: <searchLink fieldCode="AU" term="%22Giron+LB%22">Giron LB</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Shaikh+MW%22">Shaikh MW</searchLink>; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Cantu+Jungles+TM%22">Cantu Jungles TM</searchLink>; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Engen+PA%22">Engen PA</searchLink>; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Bulut+N%22">Bulut N</searchLink>; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Hasson+JM%22">Hasson JM</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+E%22">Zhang E</searchLink>; Department of Cell and Developmental Biology, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Shankaran+S%22">Shankaran S</searchLink>; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Neumann+C%22">Neumann C</searchLink>; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Villanueva+M%22">Villanueva M</searchLink>; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Landay+AL%22">Landay AL</searchLink>; Department of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.<br /><searchLink fieldCode="AU" term="%22Hope+TJ%22">Hope TJ</searchLink>; Department of Cell and Developmental Biology, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Palella+FJ%22">Palella FJ</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Corley+MJ%22">Corley MJ</searchLink>; University of California San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Tateno+H%22">Tateno H</searchLink>; Cellular and Molecular Biotechnology Research Institute, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8566, Japan.<br /><searchLink fieldCode="AU" term="%22Hamaker+B%22">Hamaker B</searchLink>; Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, West Lafayette, IN 47907, USA.<br /><searchLink fieldCode="AU" term="%22Auslander+N%22">Auslander N</searchLink>; The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Redondo+RL%22">Redondo RL</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Keshavarzian+A%22">Keshavarzian A</searchLink>; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL 60612, USA.; Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Abdel-Mohsen+M%22">Abdel-Mohsen M</searchLink>; Division of Infectious Diseases, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Center for Human Immunobiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.; Potocsnak Longevity Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
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