Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.

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Title: Placental DNA methylation captures shared and trait-specific genetic susceptibility across complex health conditions.
Authors: Cilleros-Portet A; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., González-Moro I; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Sadikki H; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marí S; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Everson TM; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Hernangómez-Laderas A; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Broséus L; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 Grenoble, France., Tost J; Laboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France., Cosín-Tomàs M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Barcelona InTerdisciplinary research group on plAnetary heaLth (BITAL), Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain., Groleau M; Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada., Czamara D; Department Genes and Environment, Max-Planck-Institute of Psychiatry, Germany., Lozano M; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Valencia, Spain.; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-University of València, Valencia, Spain., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tuhkanen J; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Fallin MD; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Schmidt RJ; Department of Public Health Sciences, University of California Davis, Davis, CA, USA., Breeze CE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Deleuze JF; Laboratory for Functional Genomics, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, Université Paris - Saclay, Evry, France., Aguilar-Lacasaña S; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Jacques PE; Department of Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Sherbrooke, QC, Canada., Hytti S; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Irizar A; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Department of Preventive Medicine and Public Health, Biogipuzkoa Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain., Lahti-Pulkkinen M; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Bakulski KM; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Dou J; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Lahti J; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland., Vrijheid M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Räikkönen K; Department of Psychology, Faculty of Medicine, University of Helsinki, Finland., Hivert MF; Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada., Sunyer J; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Heude B; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Lifecourse Epidemiology, OPPaLE, F-75004 Paris, France., Lepeule J; Université Grenoble Alpes, INSERM U1209, CNRS UMR 5309. Institut pour l'Avancée des Biosciences (IAB), Team of Environmental Epidemiology Applied to Development and Respiratory Health, 38000 GRENOBLE, France., London SJ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA., Chen J; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bustamante M; ISGlobal, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain., Marsit CJ; Gangarosa Department of Environmental Health, Emory University Rollins School of Public Health, Atlanta, GA, USA., Bilbao JR; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain., Lesseur C; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fernandez-Jimenez N; Department of Genetics, Physical Anthropology and Animal Physiology, Biobizkaia Health Research Institute and University of the Basque Country (UPV/EHU), Leioa, Spain.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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