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Endoplasmic reticulum stress in steroid-induced osteonecrosis: translational bottlenecks and targeted therapeutic strategies.

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Title: Endoplasmic reticulum stress in steroid-induced osteonecrosis: translational bottlenecks and targeted therapeutic strategies.
Authors: Liu T; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Shen Y; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Wang W; Huadong Hospital Affiliated to Fudan University, Shanghai, China., Fu F; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Yuan M; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Huang J; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Xu H; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., He Y; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Jia H; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Wang J; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Wei X; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China., Zhang H; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China., Gao X; Huadong Hospital Affiliated to Fudan University, Shanghai, China., Tang D; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jul 02; Vol. 17, pp. 1856325. Date of Electronic Publication: 2026 Jul 02 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yuan+M%22">Yuan M</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; 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Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wei+X%22">Wei X</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, China.; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Gao+X%22">Gao X</searchLink>; Huadong Hospital Affiliated to Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tang+D%22">Tang D</searchLink>; Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; 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