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Liver-to-kidney apolipoprotein J trans-accumulation exacerbates diabetic renal injury by disrupting TFEB-mediated lipid homeostasis.

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Title: Liver-to-kidney apolipoprotein J trans-accumulation exacerbates diabetic renal injury by disrupting TFEB-mediated lipid homeostasis.
Authors: Duan S; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China., Qin N; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Pi J; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.; Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China., Huang CP; Division of Nephrology, Department of Internal Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu, Taiwan., Sun P; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.; Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China., Huang Q; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China., Ke K; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China., Mo Z; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China., Jan HC; Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Division of Urology, Department of Surgery, National Cheng Kung University Hospital Dou-Liou Branch, DouLiou, Taiwan., Wang HT; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Liu WC; Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan., Chi LC; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Liu L; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China., Shi L; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China., Yang SR; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Sun HY; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Hysun@gs.ncku.edu.tw.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Hysun@gs.ncku.edu.tw.
Source: Diabetologia [Diabetologia] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liver-to-kidney apolipoprotein J trans-accumulation exacerbates diabetic renal injury by disrupting TFEB-mediated lipid homeostasis.
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  Data: <searchLink fieldCode="AU" term="%22Duan+S%22">Duan S</searchLink>; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Qin+N%22">Qin N</searchLink>; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Pi+J%22">Pi J</searchLink>; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.; Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Huang+CP%22">Huang CP</searchLink>; Division of Nephrology, Department of Internal Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sun+P%22">Sun P</searchLink>; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.; Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Huang+Q%22">Huang Q</searchLink>; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Ke+K%22">Ke K</searchLink>; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Mo+Z%22">Mo Z</searchLink>; Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Ministry of Education, Nanning, China.; Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Jan+HC%22">Jan HC</searchLink>; Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Division of Urology, Department of Surgery, National Cheng Kung University Hospital Dou-Liou Branch, DouLiou, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HT%22">Wang HT</searchLink>; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+WC%22">Liu WC</searchLink>; Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chi+LC%22">Chi LC</searchLink>; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Shi+L%22">Shi L</searchLink>; Department of Biomedical Engineering, College of Biology, Hunan University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Yang+SR%22">Yang SR</searchLink>; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Sun+HY%22">Sun HY</searchLink>; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Hysun@gs.ncku.edu.tw.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Hysun@gs.ncku.edu.tw.
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        Value: 10.1007/s00125-026-06801-7
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        Text: English
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      – TitleFull: Liver-to-kidney apolipoprotein J trans-accumulation exacerbates diabetic renal injury by disrupting TFEB-mediated lipid homeostasis.
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              Text: 2026 Jul 17
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              Y: 2026
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