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Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.

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Title: Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.
Authors: Banerjee C; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Singh RK; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Choudhary D; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Khan MN; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Maurya PK; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Khan Z; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India., Mehan S; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India. sidh.mehan@gmail.com.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India. sidh.mehan@gmail.com., Samant R; Chief Scientific Officer, Celagenex Research, Thane, Mumbai, India., Tongra M; Chief Scientific Officer, Celagenex Research, Thane, Mumbai, India.
Source: Immunologic research [Immunol Res] 2026 Jul 17; Vol. 74 (1). Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article; Review
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.
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  Data: <searchLink fieldCode="AU" term="%22Banerjee+C%22">Banerjee C</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.<br /><searchLink fieldCode="AU" term="%22Singh+RK%22">Singh RK</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.<br /><searchLink fieldCode="AU" term="%22Choudhary+D%22">Choudhary D</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.<br /><searchLink fieldCode="AU" term="%22Khan+MN%22">Khan MN</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.<br /><searchLink fieldCode="AU" term="%22Maurya+PK%22">Maurya PK</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.<br /><searchLink fieldCode="AU" term="%22Khan+Z%22">Khan Z</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.<br /><searchLink fieldCode="AU" term="%22Mehan+S%22">Mehan S</searchLink>; Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India. sidh.mehan@gmail.com.; Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India. sidh.mehan@gmail.com.<br /><searchLink fieldCode="AU" term="%22Samant+R%22">Samant R</searchLink>; Chief Scientific Officer, Celagenex Research, Thane, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Tongra+M%22">Tongra M</searchLink>; Chief Scientific Officer, Celagenex Research, Thane, Mumbai, India.
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  Data: <searchLink fieldCode="JN" term="%228611087%22">Immunologic research</searchLink> [Immunol Res] 2026 Jul 17; Vol. 74 (1). <i>Date of Electronic Publication: </i>2026 Jul 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8611087 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-0755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220257277X%22">0257277X </searchLink><i>NLM ISO Abbreviation: </i>Immunol Res <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 17
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