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Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model.

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Title: Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model.
Authors: Mihara A; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Yukata K; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Nishida N; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Seto T; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Iwanaga R; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Fujii K; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Uehara K; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Saeki Y; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Ohgi J; Faculty of Engineering, Yamaguchi University, Ube, Yamaguchi, Japan., Tsuji S; Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Asagiri M; Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan., Sakai T; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
Source: PloS one [PLoS One] 2026 Jul 17; Vol. 21 (7), pp. e0354181. Date of Electronic Publication: 2026 Jul 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sequential administration of sclerostin antibody and parathyroid hormone differentially modulates fracture healing in a murine tibial osteotomy model.
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  Data: <searchLink fieldCode="AU" term="%22Mihara+A%22">Mihara A</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Yukata+K%22">Yukata K</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Nishida+N%22">Nishida N</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Seto+T%22">Seto T</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Iwanaga+R%22">Iwanaga R</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Fujii+K%22">Fujii K</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Uehara+K%22">Uehara K</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Saeki+Y%22">Saeki Y</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Ohgi+J%22">Ohgi J</searchLink>; Faculty of Engineering, Yamaguchi University, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuji+S%22">Tsuji S</searchLink>; Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Asagiri+M%22">Asagiri M</searchLink>; Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+T%22">Sakai T</searchLink>; Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Jul 17; Vol. 21 (7), pp. e0354181. <i>Date of Electronic Publication: </i>2026 Jul 17 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE
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