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Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemic Schistosoma mansoni.

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Title: Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemic Schistosoma mansoni.
Authors: Berger DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Park SK; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA., Crellen T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College Faculty of Medicine, London, UK., Vianney TJ; Division of Biomedical Engineering, University of Glasgow, Glasgow, UK., Kabatereine NB; Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda., Cotton JA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK., Sanya R; Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute., Elliott A; Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute., Tukahebwa EM; Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda., Adriko M; Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda., Standley CJ; Center for Global Health Science and Security, Georgetown University, 3900 Reservoir Rd NW, Washington, DC, USA., Gouvras A; Global Schistosomiasis Alliance, Podium Space-Ealing Cross, 85 Uxbridge Road, London, UK., Kinung'hi S; National Institute for Medical Research (NIMR) Mwanza Centre, P.O. Box 1462, Mwanza, United Republic of Tanzania., Rabone M; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK., Emery A; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK., Lamberton PHL; School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK., Webster BL; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK., Allan F; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.; University of St Andrews, Pelagic Ecology Research Group, Scottish Oceans Institute, St. Andrews, UK., Buddenborg S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Berriman M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Marchant JS; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK., Doyle SR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK., Webster JP; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College Faculty of Medicine, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Herts, UK.
Source: Science advances [Sci Adv] 2026 Jul 17; Vol. 12 (29), pp. eadt3721. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemic Schistosoma mansoni.
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  Data: <searchLink fieldCode="AU" term="%22Berger+DJ%22">Berger DJ</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Park+SK%22">Park SK</searchLink>; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Crellen+T%22">Crellen T</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College Faculty of Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Vianney+TJ%22">Vianney TJ</searchLink>; Division of Biomedical Engineering, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kabatereine+NB%22">Kabatereine NB</searchLink>; Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Cotton+JA%22">Cotton JA</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Sanya+R%22">Sanya R</searchLink>; Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute.<br /><searchLink fieldCode="AU" term="%22Elliott+A%22">Elliott A</searchLink>; Immunomodulation and Vaccines Programme, Medical Research Council/Uganda Virus Research Institute.<br /><searchLink fieldCode="AU" term="%22Tukahebwa+EM%22">Tukahebwa EM</searchLink>; Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Adriko+M%22">Adriko M</searchLink>; Vector Borne & Neglected Tropical Disease Control Division, Ministry of Health, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Standley+CJ%22">Standley CJ</searchLink>; Center for Global Health Science and Security, Georgetown University, 3900 Reservoir Rd NW, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Gouvras+A%22">Gouvras A</searchLink>; Global Schistosomiasis Alliance, Podium Space-Ealing Cross, 85 Uxbridge Road, London, UK.<br /><searchLink fieldCode="AU" term="%22Kinung'hi+S%22">Kinung'hi S</searchLink>; National Institute for Medical Research (NIMR) Mwanza Centre, P.O. Box 1462, Mwanza, United Republic of Tanzania.<br /><searchLink fieldCode="AU" term="%22Rabone+M%22">Rabone M</searchLink>; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.<br /><searchLink fieldCode="AU" term="%22Emery+A%22">Emery A</searchLink>; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.<br /><searchLink fieldCode="AU" term="%22Lamberton+PHL%22">Lamberton PHL</searchLink>; School of Biodiversity, One Health, and Veterinary Medicine, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Webster+BL%22">Webster BL</searchLink>; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.<br /><searchLink fieldCode="AU" term="%22Allan+F%22">Allan F</searchLink>; Wolfson Wellcome Biomedical Laboratories, Department of Life Sciences, The Natural History Museum, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.; University of St Andrews, Pelagic Ecology Research Group, Scottish Oceans Institute, St. Andrews, UK.<br /><searchLink fieldCode="AU" term="%22Buddenborg+S%22">Buddenborg S</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Berriman+M%22">Berriman M</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.<br /><searchLink fieldCode="AU" term="%22Marchant+JS%22">Marchant JS</searchLink>; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.<br /><searchLink fieldCode="AU" term="%22Doyle+SR%22">Doyle SR</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.<br /><searchLink fieldCode="AU" term="%22Webster+JP%22">Webster JP</searchLink>; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College Faculty of Medicine, London, UK.; Global Centre for Neglected Tropical Disease Research (GCNTDR), Herts, UK.; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Herts, UK.
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