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Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis.

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Title: Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis.
Authors: Biancur DE; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA., Venkatesh H; Department of Chemistry, New York University, New York, NY 10003, USA., Crawford A; Department of Chemistry, New York University, New York, NY 10003, USA., Jeong Y; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA., Sohn ASW; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA., Kapner KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yamamoto K; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA.; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Lin EY; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Banh RS; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine; New York, New York 10016, USA., Assi M; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA., Shapiro B; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine; New York, New York 10016, USA., Yu P; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Division of Hematology & Medical Oncology, New York University Medical Center; New York, NY 10016 USA., Song SC; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA., Coetzee WA; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine; New York, New York 10016, USA.; Division of Hematology & Medical Oncology, New York University Medical Center; New York, NY 10016 USA.; Department of Neuroscience & Physiology, NYU Grossman School of Medicine, New York, NY 10016 USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jones AN; Department of Chemistry, New York University, New York, NY 10003, USA., Kimmelman AC; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA., Possemato R; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.
Source: Science advances [Sci Adv] 2026 Jul 17; Vol. 12 (29), pp. eadz8681. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Iron overload suppresses LKB1 and induces IL36G anti-tumor immunity in PDAC metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Biancur+DE%22">Biancur DE</searchLink>; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Venkatesh+H%22">Venkatesh H</searchLink>; Department of Chemistry, New York University, New York, NY 10003, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+A%22">Crawford A</searchLink>; Department of Chemistry, New York University, New York, NY 10003, USA.<br /><searchLink fieldCode="AU" term="%22Jeong+Y%22">Jeong Y</searchLink>; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Sohn+ASW%22">Sohn ASW</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Kapner+KS%22">Kapner KS</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA.; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Lin+EY%22">Lin EY</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Banh+RS%22">Banh RS</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine; New York, New York 10016, USA.<br /><searchLink fieldCode="AU" term="%22Assi+M%22">Assi M</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+B%22">Shapiro B</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine; New York, New York 10016, USA.<br /><searchLink fieldCode="AU" term="%22Yu+P%22">Yu P</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Division of Hematology & Medical Oncology, New York University Medical Center; New York, NY 10016 USA.<br /><searchLink fieldCode="AU" term="%22Song+SC%22">Song SC</searchLink>; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.<br /><searchLink fieldCode="AU" term="%22Coetzee+WA%22">Coetzee WA</searchLink>; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine; New York, New York 10016, USA.; Division of Hematology & Medical Oncology, New York University Medical Center; New York, NY 10016 USA.; Department of Neuroscience & Physiology, NYU Grossman School of Medicine, New York, NY 10016 USA.<br /><searchLink fieldCode="AU" term="%22Aguirre+AJ%22">Aguirre AJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Jones+AN%22">Jones AN</searchLink>; Department of Chemistry, New York University, New York, NY 10003, USA.<br /><searchLink fieldCode="AU" term="%22Kimmelman+AC%22">Kimmelman AC</searchLink>; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.; Department of Radiation Oncology. New York University Medical Center; New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Possemato+R%22">Possemato R</searchLink>; Department of Pathology, New York University Grossman School of Medicine; New York, NY 10016 USA.; Perlmutter Cancer Center, New York University Grossman School of Medicine; New York, NY 10016, USA.
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