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Baseline and placebo-related imaging, cerebrospinal fluid, plasma biomarker, and cognitive findings in unimpaired PSEN1 E280A mutation carriers and non-carriers in the Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial.

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Title: Baseline and placebo-related imaging, cerebrospinal fluid, plasma biomarker, and cognitive findings in unimpaired PSEN1 E280A mutation carriers and non-carriers in the Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial.
Authors: Bittner T; Genentech, Inc., South San Francisco, CA, USA; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Lopera F; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Rios-Romenets S; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Schiffman C; Genentech, Inc., South San Francisco, CA, USA., Clayton D; Genentech, Inc., South San Francisco, CA, USA., Hibar D; Genentech, Inc., South San Francisco, CA, USA., Kollmorgen G; Roche Diagnostics, Penzberg, Germany., Dolton M; Genentech, Inc., South San Francisco, CA, USA., Poon V; Genentech, Inc., South San Francisco, CA, USA., Nguyen J; Genentech, Inc., South San Francisco, CA, USA., Giraldo-Chica M; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Acosta-Baena N; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Espinosa A; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia; Hospital San Juan de Dios de Yarumal, Antioquia, Colombia., Villegas G; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Muñoz C; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Serna L; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia., Alvarez S; Hospital Pablo Tobón Uribe, Medellín, Colombia., Protas H; Banner Alzheimer's Institute, Phoenix, AZ, USA., Luo J; Banner Alzheimer's Institute, Phoenix, AZ, USA., Sohankar J; Banner Alzheimer's Institute, Phoenix, AZ, USA., Chen Y; Banner Alzheimer's Institute, Phoenix, AZ, USA., Ghisays V; Banner Alzheimer's Institute, Phoenix, AZ, USA., Malek-Ahmadi M; Banner Alzheimer's Institute, Phoenix, AZ, USA., Ashton NJ; Banner Alzheimer's Institute, Phoenix, AZ, USA; Banner Sun Health Research Institute, Sun City, AZ, USA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Denkinger MN; Banner Sun Health Research Institute, Sun City, AZ, USA., Cai Y; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Xu YR; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ostaszewski B; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Selkoe DJ; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Alexander RC; Banner Alzheimer's Institute, Phoenix, AZ, USA., Quiroz YT; Departments of Psychiatry and Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA., Su Y; Banner Alzheimer's Institute, Phoenix, AZ, USA., Chen K; Banner Alzheimer's Institute, Phoenix, AZ, USA., Doody RS; Genentech, Inc., South San Francisco, CA, USA; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Langbaum JB; Banner Alzheimer's Institute, Phoenix, AZ, USA., Tariot PN; Banner Alzheimer's Institute, Phoenix, AZ, USA., Sink KM; Genentech, Inc., South San Francisco, CA, USA., Reiman EM; Banner Alzheimer's Institute, Phoenix, AZ, USA. Electronic address: Eric.Reiman@bannerhealth.com.
Source: EBioMedicine [EBioMedicine] 2026 Jul 17; Vol. 130, pp. 106390. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Baseline and placebo-related imaging, cerebrospinal fluid, plasma biomarker, and cognitive findings in unimpaired PSEN1 E280A mutation carriers and non-carriers in the Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Colombia Trial.
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Hoffmann-La Roche Ltd, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lopera+F%22">Lopera F</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Rios-Romenets+S%22">Rios-Romenets S</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Schiffman+C%22">Schiffman C</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Clayton+D%22">Clayton D</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hibar+D%22">Hibar D</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kollmorgen+G%22">Kollmorgen G</searchLink>; Roche Diagnostics, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dolton+M%22">Dolton M</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Poon+V%22">Poon V</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+J%22">Nguyen J</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Giraldo-Chica+M%22">Giraldo-Chica M</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Acosta-Baena+N%22">Acosta-Baena N</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Espinosa+A%22">Espinosa A</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia; Hospital San Juan de Dios de Yarumal, Antioquia, Colombia.<br /><searchLink fieldCode="AU" term="%22Villegas+G%22">Villegas G</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Muñoz+C%22">Muñoz C</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Serna+L%22">Serna L</searchLink>; Neuroscience Group of Antioquia, University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Alvarez+S%22">Alvarez S</searchLink>; Hospital Pablo Tobón Uribe, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Protas+H%22">Protas H</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Sohankar+J%22">Sohankar J</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ghisays+V%22">Ghisays V</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Malek-Ahmadi+M%22">Malek-Ahmadi M</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Ashton+NJ%22">Ashton NJ</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA; Banner Sun Health Research Institute, Sun City, AZ, USA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Denkinger+MN%22">Denkinger MN</searchLink>; Banner Sun Health Research Institute, Sun City, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+YR%22">Xu YR</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ostaszewski+B%22">Ostaszewski B</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Selkoe+DJ%22">Selkoe DJ</searchLink>; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+RC%22">Alexander RC</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Quiroz+YT%22">Quiroz YT</searchLink>; Departments of Psychiatry and Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Doody+RS%22">Doody RS</searchLink>; Genentech, Inc., South San Francisco, CA, USA; F. Hoffmann-La Roche Ltd, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Langbaum+JB%22">Langbaum JB</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Tariot+PN%22">Tariot PN</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Sink+KM%22">Sink KM</searchLink>; Genentech, Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Reiman+EM%22">Reiman EM</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA. Electronic address: Eric.Reiman@bannerhealth.com.
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  Data: <searchLink fieldCode="JN" term="%22101647039%22">EBioMedicine</searchLink> [EBioMedicine] 2026 Jul 17; Vol. 130, pp. 106390. <i>Date of Electronic Publication: </i>2026 Jul 17.
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