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Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial.

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Title: Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial.
Authors: Moraleda C; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain. Electronic address: mariacinta.moraleda@salud.madrid.org., Tagarro A; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Servicio de Pediatría, Hospital Universitario Infanta Sofía, Fundación para la Investigación e Innovación Biomédica de los H U Infanta Sofía y el H U del Henares, Servicio Madrileño de Salud, Madrid, Spain; Faculty of Medicine, Health and Sports, Department of Medicine, Universidad Europea de Madrid, Madrid, Spain., Domínguez-Rodríguez S; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Facultad de Ciencias Biomédicas y Salud, Departamento de Biociencias, Universidad Europea de Madrid, Madrid, Spain., Musiime V; Makerere University, Kampala, Uganda., Mujuru H; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Chabala C; Department of Paediatrics, School of Medicine, University of Zambia, Lusaka, Zambia; University Teaching Hospital Children's Hospital, Lusaka, Zambia; HERPEZ, Lusaka, Zambia., Mvalo T; Lilongwe Medical Relief Trust, University of North Carolina Project Malawi, Lilongwe, Malawi; Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, NC, USA., Iroh-Tam PY; Malawi-Liverpool Wellcome Research Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK., Bramugy J; Centro de Investigação em Saúde de Manhiça, Manhiça, Mozambique., Madrid L; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; London School of Hygiene & Tropical Medicine, London, UK., Sacarlal J; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique., Passanduca A; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique., Sidat M; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique., Cassia U; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique., Aanyu HT; Mulago Hospital, Kampala, Uganda., Tagoola A; Jinja Regional Referral Hospital, Jinja, Uganda., Mutata C; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Nduna B; Arthur Davison Children's Hospital, Ndola, Zambia., Chawinga C; Lilongwe Medical Relief Trust, University of North Carolina Project Malawi, Lilongwe, Malawi., Ghambi L; Malawi-Liverpool Wellcome Research Programme, Blantyre, Malawi., Bates M; School of Natural Sciences, University of Lincoln, Lincoln, UK., Fernández-Luis S; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigação em Saúde de Manhiça, Manhiça, Mozambique; Instituto de Salud Global de Barcelona, Barcelona, Spain., Seni A; Hospital Central da Beira, Beira, Mozambique; Faculdade de Ciências de Saúde, Universidade Católica de Moçambique, Beira, Mozambique., Gafur M; Hospital Central de Nampula, Nampula, Mozambique., Nalwanga D; Makerere University, Kampala, Uganda., Nansera D; Mbarara Regional Referral Hospital, Mbarara, Uganda., Bwakura-Dangarembizi M; University of Zimbabwe Clinical Research Centre, Harare, Zimbabwe., Namuziya N; Department of Paediatrics, School of Medicine, University of Zambia, Lusaka, Zambia; University Teaching Hospital Children's Hospital, Lusaka, Zambia., Egbe FN; School of Natural Sciences, University of Lincoln, Lincoln, UK., Tembo J; HERPEZ, Lusaka, Zambia., Ballesteros Á; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain., Moh R; PAC-CI, Abiyan, Côte d'Ivoire., Manukyan L; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain., Lora D; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Universidad Complutense de Madrid, Madrid, Spain., Marcy O; University of Bordeaux, Inserm U1219, IRD EMR271, Bordeaux, France., Jacobs TG; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands., Burger D; Department of Pharmacy, Pharmacology, and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands., Bassat Q; Centro de Investigação em Saúde de Manhiça, Manhiça, Mozambique; Instituto de Salud Global de Barcelona, Barcelona, Spain; ICREA, Barcelona, Spain; Institut Clínic de Medicina I Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain; Pediatrics Department, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain; CIBER de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain., Leroy V; Centre for Epidemiology and Research in Population Health, Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse University, Toulouse, France., Nardone A; Fondazione Penta ETS, Padova, Italy., Buck WC; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique; University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA., Rojo P; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain; Universidad Complutense de Madrid, Madrid, Spain.
Corporate Authors: Empirical Clinical Trial Group
Source: Lancet (London, England) [Lancet] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, randomised, controlled, superiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Moraleda+C%22">Moraleda C</searchLink>; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Fundación Biomédica del Hospital Universitario 12 de Octubre, Madrid, Spain; Hospital Universitario 12 de Octubre, Servicio Madrileño de Salud, Madrid, Spain. 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