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Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1.

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Title: Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1.
Authors: Lujan SA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA., Arana ME; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA., Wilkins H; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA., Williams JS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA., Garbacz MA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA., Bebenek K; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA., Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA. kunkel@niehs.nih.gov.
Source: Nature communications [Nat Commun] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Two distinct Okazaki fragment failure modes dominate mutagenesis in the absence of flap endonuclease 1.
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  Data: <searchLink fieldCode="AU" term="%22Lujan+SA%22">Lujan SA</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Arana+ME%22">Arana ME</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wilkins+H%22">Wilkins H</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Williams+JS%22">Williams JS</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Garbacz+MA%22">Garbacz MA</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bebenek+K%22">Bebenek K</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kunkel+TA%22">Kunkel TA</searchLink>; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Research Triable Park, NC, USA. kunkel@niehs.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jul 17. <i>Date of Electronic Publication: </i>2026 Jul 17.
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        Value: 10.1038/s41467-026-75267-3
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              Text: 2026 Jul 17
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