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IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation.

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Title: IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation.
Authors: Liang XT; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Xie SR; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Liu XM; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China., Zhu XY; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Xiong YF; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Hong Y; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Wu ZY; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Zou YH; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China., Zhao YY; Department of Critical Care Medicine, The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, 510130, P.R. China. z-y-y116@163.com., Ding YW; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China. dingyw2011@163.com.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China. dingyw2011@163.com., Liang XS; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China. liangxiaoshan@smu.edu.cn.; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215-5400, USA. liangxiaoshan@smu.edu.cn., Xie W; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China. xieweizn@smu.edu.cn.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China. xieweizn@smu.edu.cn.
Source: The journal of headache and pain [J Headache Pain] 2026 Jul 17. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IRAK-M attenuates pain hypersensitivity and anxiety-like behaviors in a nitroglycerin-induced chronic migraine mouse model with concomitant reductions in microglial activation and neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Liang+XT%22">Liang XT</searchLink>; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xie+SR%22">Xie SR</searchLink>; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+XM%22">Liu XM</searchLink>; Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhu+XY%22">Zhu XY</searchLink>; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xiong+YF%22">Xiong YF</searchLink>; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Hong+Y%22">Hong Y</searchLink>; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wu+ZY%22">Wu ZY</searchLink>; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zou+YH%22">Zou YH</searchLink>; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhao+YY%22">Zhao YY</searchLink>; Department of Critical Care Medicine, The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, 510130, P.R. China. z-y-y116@163.com.<br /><searchLink fieldCode="AU" term="%22Ding+YW%22">Ding YW</searchLink>; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China. dingyw2011@163.com.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China. dingyw2011@163.com.<br /><searchLink fieldCode="AU" term="%22Liang+XS%22">Liang XS</searchLink>; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China. liangxiaoshan@smu.edu.cn.; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215-5400, USA. liangxiaoshan@smu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xie+W%22">Xie W</searchLink>; Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P.R. China. xieweizn@smu.edu.cn.; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, P.R. China. xieweizn@smu.edu.cn.
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        Value: 10.1186/s10194-026-02457-1
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              Text: 2026 Jul 17
              Type: published
              Y: 2026
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