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ChAdOx1 nCoV-19 coronavirus vaccine: Long-term safety and immunological responses.

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Title: ChAdOx1 nCoV-19 coronavirus vaccine: Long-term safety and immunological responses.
Authors: Ebrahimi N; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., de Whalley P; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. Electronic address: philip.dewhalley@paediatrics.ox.ac.uk., Kanji N; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Ramasamy MN; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Bibi S; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Clutterbuck EA; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Collins AM; University Hospital Liverpool Group and Liverpool School of Tropical Medicine (LSTM), Pembroke Place, Liverpool L3 5QA, UK., Darton TC; School of Medicine and Population Health, University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2RX, UK., Duncan CJA; NIHR Newcastle Clinical Research Facility, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK; Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Feng ES; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Goodman AL; Department of Infection at Guy's and St Thomas' NHS Foundation Trust, Department of Infection, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK; MRC Clinical trials unit at University College London, 90 High Holborn, London WC1V 6LJ, UK., Green CA; NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust (UHB), Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham B15 2TH, UK., Heath PT; City St Georges, University of London, Tooting, London SW17 0QT, UK., Kwok J; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Lazarus R; University Hospitals Bristol and Weston NHS Foundation Trust, Marlborough Street, Avon, Bristol BS1 3NU, UK; Bristol Medical School, University of Bristol, Queens Road, Bristol BS8 1QU, UK., Libri V; University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK., Lillie PJ; Hull University Teaching Hospitals NHS Trust (HUTH), Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, UK., McGregor A; Northwick Park Hospital, London North West University Healthcare Trust, Northwick Park Hospital, Watford Road, Harrow, HA1 3UJ, UK., Mujadidi YF; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Owino N; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Plested E; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Pollock KM; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; NIHR Imperial Clinical Research Facility, Imperial College Healthcare NHS Trust, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK., Robinson H; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Sutherland RK; Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital, Telford Road, Edinburgh EH4 2JP, UK., Thomson EC; MRC-University of Glasgow Centre for Virus Research (CVR), 464 Bearsden Road, Glasgow G61 1NH, UK; NHS Greater Glasgow and Clyde, Queen Elizabeth University Hospital (QEUH), 1345 Govan Road, Glasgow G51 4TF, UK., Toshner M; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB, UK., Turner DPJ; School of Life Sciences, University of Nottingham, University Park, Derby Road, Nottingham NG7 2RD, UK., Williams CJ; Public Health Wales, Aneurin Bevan University Health Board, St. Cadoc's Hospital, Lodge Road, Caerleon, Newport NP18 3XQ, UK., Hirsch I; Biometrics, Vaccines, & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Villafana TL; AstraZeneca, One Medimmune Way, Gaithersburg, MD 20878, USA., Lambe T; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Voysey M; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
Source: Vaccine [Vaccine] 2026 Jul 19; Vol. 88, pp. 128951. Date of Electronic Publication: 2026 Jul 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
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  Data: ChAdOx1 nCoV-19 coronavirus vaccine: Long-term safety and immunological responses.
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  Data: <searchLink fieldCode="AU" term="%22Ebrahimi+N%22">Ebrahimi N</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22de+Whalley+P%22">de Whalley P</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. 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NIHR Newcastle Clinical Research Facility, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.<br /><searchLink fieldCode="AU" term="%22Faust+SN%22">Faust SN</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK; Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Feng+ES%22">Feng ES</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.<br /><searchLink fieldCode="AU" term="%22Goodman+AL%22">Goodman AL</searchLink>; Department of Infection at Guy's and St Thomas' NHS Foundation Trust, Department of Infection, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK; MRC Clinical trials unit at University College London, 90 High Holborn, London WC1V 6LJ, UK.<br /><searchLink fieldCode="AU" term="%22Green+CA%22">Green CA</searchLink>; NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust (UHB), Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham B15 2TH, UK.<br /><searchLink fieldCode="AU" term="%22Heath+PT%22">Heath PT</searchLink>; City St Georges, University of London, Tooting, London SW17 0QT, UK.<br /><searchLink fieldCode="AU" term="%22Kwok+J%22">Kwok J</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lazarus+R%22">Lazarus R</searchLink>; University Hospitals Bristol and Weston NHS Foundation Trust, Marlborough Street, Avon, Bristol BS1 3NU, UK; Bristol Medical School, University of Bristol, Queens Road, Bristol BS8 1QU, UK.<br /><searchLink fieldCode="AU" term="%22Libri+V%22">Libri V</searchLink>; University College London Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PG, UK.<br /><searchLink fieldCode="AU" term="%22Lillie+PJ%22">Lillie PJ</searchLink>; Hull University Teaching Hospitals NHS Trust (HUTH), Hull Royal Infirmary, Anlaby Road, Hull HU3 2JZ, UK.<br /><searchLink fieldCode="AU" term="%22McGregor+A%22">McGregor A</searchLink>; Northwick Park Hospital, London North West University Healthcare Trust, Northwick Park Hospital, Watford Road, Harrow, HA1 3UJ, UK.<br /><searchLink fieldCode="AU" term="%22Mujadidi+YF%22">Mujadidi YF</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Owino+N%22">Owino N</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Plested+E%22">Plested E</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pollock+KM%22">Pollock KM</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; NIHR Imperial Clinical Research Facility, Imperial College Healthcare NHS Trust, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+H%22">Robinson H</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sutherland+RK%22">Sutherland RK</searchLink>; Clinical Infection Research Group, Regional Infectious Diseases Unit, Western General Hospital, Telford Road, Edinburgh EH4 2JP, UK.<br /><searchLink fieldCode="AU" term="%22Thomson+EC%22">Thomson EC</searchLink>; MRC-University of Glasgow Centre for Virus Research (CVR), 464 Bearsden Road, Glasgow G61 1NH, UK; NHS Greater Glasgow and Clyde, Queen Elizabeth University Hospital (QEUH), 1345 Govan Road, Glasgow G51 4TF, UK.<br /><searchLink fieldCode="AU" term="%22Toshner+M%22">Toshner M</searchLink>; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB, UK.<br /><searchLink fieldCode="AU" term="%22Turner+DPJ%22">Turner DPJ</searchLink>; School of Life Sciences, University of Nottingham, University Park, Derby Road, Nottingham NG7 2RD, UK.<br /><searchLink fieldCode="AU" term="%22Williams+CJ%22">Williams CJ</searchLink>; Public Health Wales, Aneurin Bevan University Health Board, St. Cadoc's Hospital, Lodge Road, Caerleon, Newport NP18 3XQ, UK.<br /><searchLink fieldCode="AU" term="%22Hirsch+I%22">Hirsch I</searchLink>; Biometrics, Vaccines, & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Villafana+TL%22">Villafana TL</searchLink>; AstraZeneca, One Medimmune Way, Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK; Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Voysey+M%22">Voysey M</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+AJ%22">Pollard AJ</searchLink>; Oxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
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