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Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression.

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Title: Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression.
Authors: Tibarewal P; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Cancer Institute, University College London, London, UK., Spinelli L; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK., Kriplani N; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK., Wise H; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK., Poncet N; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Division of Molecular, Cell and Developmental Biology, Faculty of Life Sciences, University of Dundee, Dundee, UK., Marzano G; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK., Anderson KE; Inositide Laboratory, Babraham Institute, Cambridge, UK., Grzes KM; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK., Varyova Z; Cancer Institute, University College London, London, UK., Adil M; Cancer Institute, University College London, London, UK., Downes CP; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK., Hawkins PT; Inositide Laboratory, Babraham Institute, Cambridge, UK., Stephens LR; Inositide Laboratory, Babraham Institute, Cambridge, UK., Storey KG; Division of Molecular, Cell and Developmental Biology, Faculty of Life Sciences, University of Dundee, Dundee, UK., Cantrell DA; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK., Vanhaesebroeck B; Cancer Institute, University College London, London, UK., Leslie NR; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.
Source: Cancer science [Cancer Sci] 2026 Jul 19. Date of Electronic Publication: 2026 Jul 19.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Tibarewal+P%22">Tibarewal P</searchLink>; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Spinelli+L%22">Spinelli L</searchLink>; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Kriplani+N%22">Kriplani N</searchLink>; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wise+H%22">Wise H</searchLink>; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Poncet+N%22">Poncet N</searchLink>; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Division of Molecular, Cell and Developmental Biology, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Marzano+G%22">Marzano G</searchLink>; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Anderson+KE%22">Anderson KE</searchLink>; Inositide Laboratory, Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Grzes+KM%22">Grzes KM</searchLink>; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Varyova+Z%22">Varyova Z</searchLink>; Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Adil+M%22">Adil M</searchLink>; Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Downes+CP%22">Downes CP</searchLink>; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Hawkins+PT%22">Hawkins PT</searchLink>; Inositide Laboratory, Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Stephens+LR%22">Stephens LR</searchLink>; Inositide Laboratory, Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Storey+KG%22">Storey KG</searchLink>; Division of Molecular, Cell and Developmental Biology, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Cantrell+DA%22">Cantrell DA</searchLink>; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Vanhaesebroeck+B%22">Vanhaesebroeck B</searchLink>; Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Leslie+NR%22">Leslie NR</searchLink>; Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot Watt University, Edinburgh, UK.; Division of Cell Signalling and Immunology, Faculty of Life Sciences, University of Dundee, Dundee, UK.
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