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Lyophilized platelet derived extracellular vesicles promote hemostasis and attenuate intracranial hemorrhage following traumatic brain injury.

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Title: Lyophilized platelet derived extracellular vesicles promote hemostasis and attenuate intracranial hemorrhage following traumatic brain injury.
Authors: Trivedi A; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Miyazawa B; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Fields AT; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Matthews M; Cellphire Therapeutics, Inc, Rockville, MD, USA., Vivona L; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Keane C; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Potter D; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Geng H; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Zhang H; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA., Taenaka H; Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA, USA.; Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Kwek SS; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA., Herrera-Rodriguez K; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Nunez-Garcia B; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., de Menezes EM; Vitalant Research Institute, San Francisco, CA, 94118, USA., Barry M; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Nair A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Kuhn B; Cellphire Therapeutics, Inc, Rockville, MD, USA., Norris PJ; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.; Vitalant Research Institute, San Francisco, CA, 94118, USA.; Department of Medicine, University of California, San Francisco, CA, USA., Fong L; Fred Hutchinson Cancer Center, Seattle, WA, USA., Fitzpatrick MM; Cellphire Therapeutics, Inc, Rockville, MD, USA., Schreiber M; Department of Surgery, Uniformed Services University, Bethesda, MD, USA., Kornblith LZ; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Pati S; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA. Shibani.pati@ucsf.edu.; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA. Shibani.pati@ucsf.edu.
Source: Journal of translational medicine [J Transl Med] 2026 Jul 20. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lyophilized platelet derived extracellular vesicles promote hemostasis and attenuate intracranial hemorrhage following traumatic brain injury.
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  Data: <searchLink fieldCode="AU" term="%22Trivedi+A%22">Trivedi A</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Miyazawa+B%22">Miyazawa B</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Fields+AT%22">Fields AT</searchLink>; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Matthews+M%22">Matthews M</searchLink>; Cellphire Therapeutics, Inc, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vivona+L%22">Vivona L</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Keane+C%22">Keane C</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Potter+D%22">Potter D</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Geng+H%22">Geng H</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Taenaka+H%22">Taenaka H</searchLink>; Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, CA, USA.; Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Kwek+SS%22">Kwek SS</searchLink>; Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Herrera-Rodriguez+K%22">Herrera-Rodriguez K</searchLink>; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nunez-Garcia+B%22">Nunez-Garcia B</searchLink>; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22de+Menezes+EM%22">de Menezes EM</searchLink>; Vitalant Research Institute, San Francisco, CA, 94118, USA.<br /><searchLink fieldCode="AU" term="%22Barry+M%22">Barry M</searchLink>; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nair+A%22">Nair A</searchLink>; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kuhn+B%22">Kuhn B</searchLink>; Cellphire Therapeutics, Inc, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Norris+PJ%22">Norris PJ</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA.; Vitalant Research Institute, San Francisco, CA, 94118, USA.; Department of Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fong+L%22">Fong L</searchLink>; Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+MM%22">Fitzpatrick MM</searchLink>; Cellphire Therapeutics, Inc, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schreiber+M%22">Schreiber M</searchLink>; Department of Surgery, Uniformed Services University, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kornblith+LZ%22">Kornblith LZ</searchLink>; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pati+S%22">Pati S</searchLink>; Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSE 715, San Francisco, CA, 94143, USA. Shibani.pati@ucsf.edu.; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA. Shibani.pati@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Jul 20. <i>Date of Electronic Publication: </i>2026 Jul 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08638-5
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        Text: English
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              Text: 2026 Jul 20
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