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Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials.

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Title: Sodium bicarbonate therapy in severe metabolic acidemia: an individual patient data meta-analysis of the BICAR-ICU and BICAR-ICU2 trials.
Authors: Fosset M; Medical Intensive Care Unit, CHU Montpellier, 191, Avenue du Doyen Gaston Giraud, Montpellier, Cedex 5, 34295, France.; IDESP, Univ Montpellier, INSERM, PreMEdical, INRIA, CHU Montpellier, Montpellier, France, University of Montpellier, Montpellier, 34295, France., Pensier J; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France., Jabaudon M; Department of Perioperative Medicine, CHU Clermont-Ferrand, Clermont-Ferrand, France.; CNRS, INSERM, Université Clermont Auvergne, Clermont-Ferrand, France., Bitker L; Medical Intensive Care Unit, La Croix Rousse Hospital, Lyon, France.; Lyon University Hospital, Lyon, France., De Jong A; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France., Chanques G; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France., Huguet H; Epidemiology and Clinical Research Department, Montpellier University Hospital, Université de Montpellier, Montpellier, France., Molinari N; IDESP, Univ Montpellier, INSERM, PreMEdical, INRIA, CHU Montpellier, Montpellier, France, University of Montpellier, Montpellier, 34295, France., Jaber S; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France., Jung B; Medical Intensive Care Unit, CHU Montpellier, 191, Avenue du Doyen Gaston Giraud, Montpellier, Cedex 5, 34295, France. b-jung@chu-montpellier.fr.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France. b-jung@chu-montpellier.fr.
Source: Critical care (London, England) [Crit Care] 2026 Jul 19. Date of Electronic Publication: 2026 Jul 19.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fosset+M%22">Fosset M</searchLink>; Medical Intensive Care Unit, CHU Montpellier, 191, Avenue du Doyen Gaston Giraud, Montpellier, Cedex 5, 34295, France.; IDESP, Univ Montpellier, INSERM, PreMEdical, INRIA, CHU Montpellier, Montpellier, France, University of Montpellier, Montpellier, 34295, France.<br /><searchLink fieldCode="AU" term="%22Pensier+J%22">Pensier J</searchLink>; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France.<br /><searchLink fieldCode="AU" term="%22Jabaudon+M%22">Jabaudon M</searchLink>; Department of Perioperative Medicine, CHU Clermont-Ferrand, Clermont-Ferrand, France.; CNRS, INSERM, Université Clermont Auvergne, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Bitker+L%22">Bitker L</searchLink>; Medical Intensive Care Unit, La Croix Rousse Hospital, Lyon, France.; Lyon University Hospital, Lyon, France.<br /><searchLink fieldCode="AU" term="%22De+Jong+A%22">De Jong A</searchLink>; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France.<br /><searchLink fieldCode="AU" term="%22Chanques+G%22">Chanques G</searchLink>; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France.<br /><searchLink fieldCode="AU" term="%22Huguet+H%22">Huguet H</searchLink>; Epidemiology and Clinical Research Department, Montpellier University Hospital, Université de Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Molinari+N%22">Molinari N</searchLink>; IDESP, Univ Montpellier, INSERM, PreMEdical, INRIA, CHU Montpellier, Montpellier, France, University of Montpellier, Montpellier, 34295, France.<br /><searchLink fieldCode="AU" term="%22Jaber+S%22">Jaber S</searchLink>; Department of Anesthesia and Intensive Care unit, St-Eloi Hospital, Regional University Hospital of Montpellier, University of Montpellier, CEDEX 5, Montpellier, France.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France.<br /><searchLink fieldCode="AU" term="%22Jung+B%22">Jung B</searchLink>; Medical Intensive Care Unit, CHU Montpellier, 191, Avenue du Doyen Gaston Giraud, Montpellier, Cedex 5, 34295, France. b-jung@chu-montpellier.fr.; University of Montpellier, INSERM U1046, CNRS UMR, Montpellier, 9214, France. b-jung@chu-montpellier.fr.
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              Text: 2026 Jul 19
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