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Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction.

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Title: Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction.
Authors: Packer M; Baylor Heart and Vascular Institute, Dallas, TX (M.P.).; Imperial College, London, UK (M.P.)., Schiattarella GG; Max Rubner Center for Cardiovascular Metabolic Renal Research (MRC), Deutsches Herzzentrum der Charité (DHZC), Charité-Universitätsmedizin Berlin, Germany (G.G.S.).; Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy (G.G.S.)., Petrie MC; School of Cardiovascular and Metabolic Health, University of Glasgow, UK (M.C.P.)., Burkhoff D; Cardiovascular Research Foundation, New York, NY (D.B.)., Butler J; Baylor Scott & White Research Institute, Dallas, TX (J.B.).; University of Mississippi School of Medicine, Jackson (J.B.)., Lam CSP; Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore Medical School (C.S.P.L.).; National Heart Centre Singapore (C.S.P.L.)., Zannad F; Université de Lorraine, Centres d'Investigation Clinique, INSERM, Centre Hospitalier Régional Universitaire de Nancy, France (F.Z.)., Vaduganathan M; Division of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.V.)., Borlaug BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (B.A.B.).
Source: Circulation [Circulation] 2026 Jul 21; Vol. 154 (3), pp. 271-287. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article; Review
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction.
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  Data: <searchLink fieldCode="JN" term="%220147763%22">Circulation</searchLink> [Circulation] 2026 Jul 21; Vol. 154 (3), pp. 271-287. <i>Date of Electronic Publication: </i>2026 Jul 20.
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        Value: 10.1161/CIRCULATIONAHA.126.079235
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              Text: 2026 Jul 21
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