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Safety and preliminary efficacy of allogeneic bone marrow-derived mesenchymal stromal cells (BMSC) for painful lumbar facet arthropathy: study protocol for a randomised, double-blinded, placebo-controlled, crossover phase II clinical trial.

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Title: Safety and preliminary efficacy of allogeneic bone marrow-derived mesenchymal stromal cells (BMSC) for painful lumbar facet arthropathy: study protocol for a randomised, double-blinded, placebo-controlled, crossover phase II clinical trial.
Authors: Yan D; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA., Durand NC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA., Wang Z; Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota, USA.; Robert D and Patricia E Kern Center for the Science of Health Care Delivery, Mayo Clinic Minnesota, Rochester, Minnesota, USA., Osborne MD; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA., Stone JA; Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA., Gupta S; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA., Miller DA; Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA., Witter DM; Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA., Eldrige JS; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA., Quiñones-Hinojosa A; Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA., Zubair AC; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA., Qu W; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA Qu.Wenchun@mayo.edu.; Center for Regenerative Biotherapeutics, Mayo Clinic in Florida, Jacksonville, Florida, USA.
Source: BMJ open [BMJ Open] 2026 Jul 20; Vol. 16 (7), pp. e113509. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and preliminary efficacy of allogeneic bone marrow-derived mesenchymal stromal cells (BMSC) for painful lumbar facet arthropathy: study protocol for a randomised, double-blinded, placebo-controlled, crossover phase II clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Yan+D%22">Yan D</searchLink>; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Durand+NC%22">Durand NC</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota, USA.; Robert D and Patricia E Kern Center for the Science of Health Care Delivery, Mayo Clinic Minnesota, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Osborne+MD%22">Osborne MD</searchLink>; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Stone+JA%22">Stone JA</searchLink>; Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Miller+DA%22">Miller DA</searchLink>; Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Witter+DM%22">Witter DM</searchLink>; Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Eldrige+JS%22">Eldrige JS</searchLink>; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Quiñones-Hinojosa+A%22">Quiñones-Hinojosa A</searchLink>; Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Zubair+AC%22">Zubair AC</searchLink>; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Qu+W%22">Qu W</searchLink>; Department of Pain Medicine, Mayo Clinic in Florida, Jacksonville, Florida, USA Qu.Wenchun@mayo.edu.; Center for Regenerative Biotherapeutics, Mayo Clinic in Florida, Jacksonville, Florida, USA.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2026 Jul 20; Vol. 16 (7), pp. e113509. <i>Date of Electronic Publication: </i>2026 Jul 20.
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  Data: Journal Article; Clinical Trial Protocol
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101552874 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2044-6055 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220446055%22">20446055 </searchLink><i>NLM ISO Abbreviation: </i>BMJ Open <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 20
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