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LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming.

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Title: LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming.
Authors: Wang Z; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.; Department of Plastic and Reconstructive Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China., Huang Q; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., Zhao J; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., Lyu Z; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., Ju F; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany., You B; Institute of Otolaryngology head and neck surgery, Affiliated Hospital of Nantong University, Nantong, PR China., Wang J; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Dong Q; Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer, Shanghai Municipal Health Commission, Minhang Hospital, Fudan University, Shanghai, PR China., Odenthal M; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Quaas A; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany., Diakopoulos KN; Comprehensive Cancer Center München, Institute for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany., Algül H; Comprehensive Cancer Center München, Institute for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany., Reichert M; Department of Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Bruns CJ; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany. christiane.bruns@uk-koeln.de., Zhao Y; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany. yue.zhao@uk-koeln.de.
Source: Cell death & disease [Cell Death Dis] 2026 Jul 20; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: LSD1-GLS2 axis drives subtype-specific chemoresistance in pancreatic cancer through glutaminolysis reprogramming.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.; Department of Plastic and Reconstructive Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China.<br /><searchLink fieldCode="AU" term="%22Huang+Q%22">Huang Q</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Lyu+Z%22">Lyu Z</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ju+F%22">Ju F</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22You+B%22">You B</searchLink>; Institute of Otolaryngology head and neck surgery, Affiliated Hospital of Nantong University, Nantong, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Dong+Q%22">Dong Q</searchLink>; Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer, Shanghai Municipal Health Commission, Minhang Hospital, Fudan University, Shanghai, PR China.<br /><searchLink fieldCode="AU" term="%22Odenthal+M%22">Odenthal M</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Quaas+A%22">Quaas A</searchLink>; Institute of Pathology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Diakopoulos+KN%22">Diakopoulos KN</searchLink>; Comprehensive Cancer Center München, Institute for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany.<br /><searchLink fieldCode="AU" term="%22Algül+H%22">Algül H</searchLink>; Comprehensive Cancer Center München, Institute for Tumor Metabolism, Klinikum rechts der Isar, Technical University of Munich, School of Medicine and Health, Munich, Bavaria, Germany.<br /><searchLink fieldCode="AU" term="%22Reichert+M%22">Reichert M</searchLink>; Department of Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bruns+CJ%22">Bruns CJ</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany. christiane.bruns@uk-koeln.de.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of General, Visceral, Thoracic and Transplantation Surgery, University Hospital of Cologne, Cologne, Germany. yue.zhao@uk-koeln.de.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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