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A prospective national precision medicine trial evaluating the feasibility of blood-based molecular profiling in patients with Cancer of Unknown Primary (CUP-COMP).

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Title: A prospective national precision medicine trial evaluating the feasibility of blood-based molecular profiling in patients with Cancer of Unknown Primary (CUP-COMP).
Authors: Conway AM; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Cancer Research UK National Biomarker Centre, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Robinson M; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Concannon M; The Christie NHS Foundation Trust, Manchester, UK., Clive S; Edinburgh Cancer Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Tillett T; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Shiu KK; University College London & University College London Hospitals NHS Foundation Trust, London, UK., Medley L; Torbay and South Devon NHS Foundation Trust, Torquay, UK., Dasgupta S; Velindre University NHS Trust, Cardiff, UK., Ahmed E; The Clatterbridge Cancer Centre, Liverpool, UK., Warrington K; Roche Products Limited, Welwyn Garden City, UK., Mahmood U; The Christie NHS Foundation Trust, Manchester, UK., Zair Z; The Christie NHS Foundation Trust, Manchester, UK., Gillham T; The Christie NHS Foundation Trust, Manchester, UK., Davis A; Torbay and South Devon NHS Foundation Trust, Torquay, UK., Scott JA; Northern Ireland Cancer Centre, Belfast, UK., Taylor A; The Clatterbridge Cancer Centre, Liverpool, UK., Stares M; Edinburgh Cancer Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK., Mitchell C; The Christie NHS Foundation Trust, Manchester, UK., Oliviera P; The Christie NHS Foundation Trust, Manchester, UK., Burghel GJ; Manchester Centre for Genomic Medicine and North West genomic laboratory Hub, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.; Division of Evolution, Infection, and Genomic Sciences, The University of Manchester, Manchester, UK., Cook N; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Natalie.cook17@nhs.net.; The Christie NHS Foundation Trust, Manchester, UK. Natalie.cook17@nhs.net.
Source: British journal of cancer [Br J Cancer] 2026 Jul 20. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Conway+AM%22">Conway AM</searchLink>; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.; Cancer Research UK National Biomarker Centre, The University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+M%22">Robinson M</searchLink>; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Concannon+M%22">Concannon M</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Clive+S%22">Clive S</searchLink>; Edinburgh Cancer Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Tillett+T%22">Tillett T</searchLink>; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK.<br /><searchLink fieldCode="AU" term="%22Shiu+KK%22">Shiu KK</searchLink>; University College London & University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Medley+L%22">Medley L</searchLink>; Torbay and South Devon NHS Foundation Trust, Torquay, UK.<br /><searchLink fieldCode="AU" term="%22Dasgupta+S%22">Dasgupta S</searchLink>; Velindre University NHS Trust, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Ahmed+E%22">Ahmed E</searchLink>; The Clatterbridge Cancer Centre, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Warrington+K%22">Warrington K</searchLink>; Roche Products Limited, Welwyn Garden City, UK.<br /><searchLink fieldCode="AU" term="%22Mahmood+U%22">Mahmood U</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Zair+Z%22">Zair Z</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Gillham+T%22">Gillham T</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Davis+A%22">Davis A</searchLink>; Torbay and South Devon NHS Foundation Trust, Torquay, UK.<br /><searchLink fieldCode="AU" term="%22Scott+JA%22">Scott JA</searchLink>; Northern Ireland Cancer Centre, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+A%22">Taylor A</searchLink>; The Clatterbridge Cancer Centre, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Stares+M%22">Stares M</searchLink>; Edinburgh Cancer Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Mitchell+C%22">Mitchell C</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Oliviera+P%22">Oliviera P</searchLink>; The Christie NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Burghel+GJ%22">Burghel GJ</searchLink>; Manchester Centre for Genomic Medicine and North West genomic laboratory Hub, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.; Division of Evolution, Infection, and Genomic Sciences, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Cook+N%22">Cook N</searchLink>; Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Natalie.cook17@nhs.net.; The Christie NHS Foundation Trust, Manchester, UK. Natalie.cook17@nhs.net.
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