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Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy.

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Title: Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy.
Authors: Fabbri L; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France. lucilla.fabbri@curie.fr.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France. lucilla.fabbri@curie.fr.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France. lucilla.fabbri@curie.fr., Lagadec L; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France., Guérin E; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France., Lecourt H; INSERM U981, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris-Sud, Université Paris-Saclay, Kremlin-Bicêtre, France.; Dermato-Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Baille D; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France., Besse L; Institut Curie, PSL University, CNRS UAR2016, Inserm US43, Université Paris-Saclay, Multimodal Imaging Center, Orsay, France., Messaoudi C; Institut Curie, PSL University, CNRS UAR2016, Inserm US43, Université Paris-Saclay, Multimodal Imaging Center, Orsay, France., Désaubry L; Center of Research in Biomedicine of Strasbourg, Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, Strasbourg, France., Abou-Hamdan H; Center of Research in Biomedicine of Strasbourg, Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, Strasbourg, France., Roy S; INSERM U981, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris-Sud, Université Paris-Saclay, Kremlin-Bicêtre, France.; Dermato-Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Lombard B; Institut Curie, PSL University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France., Loew D; Institut Curie, PSL University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France., Scoazec JY; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800, Villejuif, France., Robert C; INSERM U981, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris-Sud, Université Paris-Saclay, Kremlin-Bicêtre, France.; Dermato-Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Vagner S; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France. stephan.vagner@curie.fr.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France. stephan.vagner@curie.fr.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France. stephan.vagner@curie.fr.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul 20. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
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  Data: Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy.
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  Data: <searchLink fieldCode="AU" term="%22Fabbri+L%22">Fabbri L</searchLink>; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France. lucilla.fabbri@curie.fr.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France. lucilla.fabbri@curie.fr.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France. lucilla.fabbri@curie.fr.<br /><searchLink fieldCode="AU" term="%22Lagadec+L%22">Lagadec L</searchLink>; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Guérin+E%22">Guérin E</searchLink>; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Lecourt+H%22">Lecourt H</searchLink>; INSERM U981, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris-Sud, Université Paris-Saclay, Kremlin-Bicêtre, France.; Dermato-Oncology, Gustave Roussy Cancer Campus, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Baille+D%22">Baille D</searchLink>; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Besse+L%22">Besse L</searchLink>; Institut Curie, PSL University, CNRS UAR2016, Inserm US43, Université Paris-Saclay, Multimodal Imaging Center, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Messaoudi+C%22">Messaoudi C</searchLink>; Institut Curie, PSL University, CNRS UAR2016, Inserm US43, Université Paris-Saclay, Multimodal Imaging Center, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Désaubry+L%22">Désaubry L</searchLink>; Center of Research in Biomedicine of Strasbourg, Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Abou-Hamdan+H%22">Abou-Hamdan H</searchLink>; Center of Research in Biomedicine of Strasbourg, Regenerative Nanomedicine (UMR 1260), INSERM, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Roy+S%22">Roy S</searchLink>; INSERM U981, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris-Sud, Université Paris-Saclay, Kremlin-Bicêtre, France.; Dermato-Oncology, Gustave Roussy Cancer Campus, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Lombard+B%22">Lombard B</searchLink>; Institut Curie, PSL University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.<br /><searchLink fieldCode="AU" term="%22Loew+D%22">Loew D</searchLink>; Institut Curie, PSL University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France.<br /><searchLink fieldCode="AU" term="%22Scoazec+JY%22">Scoazec JY</searchLink>; Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Robert+C%22">Robert C</searchLink>; INSERM U981, Gustave Roussy Cancer Campus, Villejuif, France.; Université Paris-Sud, Université Paris-Saclay, Kremlin-Bicêtre, France.; Dermato-Oncology, Gustave Roussy Cancer Campus, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Vagner+S%22">Vagner S</searchLink>; Institut Curie, PSL Research University, CNRS UMR3348, INSERM U1368, Orsay, France. stephan.vagner@curie.fr.; Université Paris-Saclay, CNRS UMR3348, INSERM U1368, Orsay, France. stephan.vagner@curie.fr.; Equipe labellisée Ligue Nationale contre le Cancer, Orsay, France. stephan.vagner@curie.fr.
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