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Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia.

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Title: Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia.
Authors: Pashai Fakhri M; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany., Börner FR; Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany., Held J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany., Sivaraman K; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany., Fuge J; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany., Rupp J; CAPNETZ STIFTUNG, Hannover, Germany.; Department of Infectious Diseases and Microbiology, University Hospital Schleswig-Holstein, Lübeck, Germany., Barten-Neiner G; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; CAPNETZ STIFTUNG, Hannover, Germany., Pletz MW; CAPNETZ STIFTUNG, Hannover, Germany.; Institute of Infectious Diseases and Infection Control, University Hospital, Jena, Germany., Witzenrath M; CAPNETZ STIFTUNG, Hannover, Germany.; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany., Rohde G; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; CAPNETZ STIFTUNG, Hannover, Germany.; Department of Respiratory, Intensive Care and Sleep Medicine, Philipps-University Marburg, Marburg, Germany., Rademacher J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; CAPNETZ STIFTUNG, Hannover, Germany., Hinze CA; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany., Janciauskiene S; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Janciauskiene.Sabina@mh-hannover.de.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Janciauskiene.Sabina@mh-hannover.de.
Corporate Authors: CAPNETZ Study Group
Source: Journal of translational medicine [J Transl Med] 2026 Jul 20; Vol. 24 (1). Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Circulating alpha-1 antitrypsin and its c-terminal peptides differentiate bacterial from viral community-acquired pneumonia.
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  Data: <searchLink fieldCode="AU" term="%22Pashai+Fakhri+M%22">Pashai Fakhri M</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Börner+FR%22">Börner FR</searchLink>; Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Held+J%22">Held J</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Sivaraman+K%22">Sivaraman K</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Fuge+J%22">Fuge J</searchLink>; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Rupp+J%22">Rupp J</searchLink>; CAPNETZ STIFTUNG, Hannover, Germany.; Department of Infectious Diseases and Microbiology, University Hospital Schleswig-Holstein, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Barten-Neiner+G%22">Barten-Neiner G</searchLink>; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; CAPNETZ STIFTUNG, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Pletz+MW%22">Pletz MW</searchLink>; CAPNETZ STIFTUNG, Hannover, Germany.; Institute of Infectious Diseases and Infection Control, University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Witzenrath+M%22">Witzenrath M</searchLink>; CAPNETZ STIFTUNG, Hannover, Germany.; Department of Infectious Diseases, Respiratory Medicine and Critical Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Rohde+G%22">Rohde G</searchLink>; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; CAPNETZ STIFTUNG, Hannover, Germany.; Department of Respiratory, Intensive Care and Sleep Medicine, Philipps-University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rademacher+J%22">Rademacher J</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; CAPNETZ STIFTUNG, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hinze+CA%22">Hinze CA</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.; Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Janciauskiene+S%22">Janciauskiene S</searchLink>; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Janciauskiene.Sabina@mh-hannover.de.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Janciauskiene.Sabina@mh-hannover.de.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-08651-8
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        Text: English
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