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Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors.

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Title: Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors.
Authors: Evdokimova V; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address: v.evdokimova@gmail.com., Ruzanov P; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Gassmann H; Department of Pediatrics, Children's Cancer Research Center, Kinderklinik München Schwabing and Institute of Pathology, 80804 Munich, Germany; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, 80804 Munich, Germany., Hung M; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Zhang Z; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Senff-Ribeiro A; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Khoshgoo N; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Zheng S; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Pachva MC; Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Ringwalt EM; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Cripe TP; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; Division of Pediatric Hematology, Oncology, and BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA., Roberts RD; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; Division of Pediatric Hematology, Oncology, and BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Burdach SEG; Department of Pediatrics, Children's Cancer Research Center, Kinderklinik München Schwabing and Institute of Pathology, 80804 Munich, Germany; CCC München Comprehensive Cancer Center, DKTK German Cancer Consortium Munich, 80804 Munich, Germany., Stein LD; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Radvanyi L; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Cancer Research Program, Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8L6, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A1, Canada. Electronic address: lradvanyi@ohri.ca.
Source: Cell reports [Cell Rep] 2026 Jul 21; Vol. 45 (7), pp. 117708. Date of Electronic Publication: 2026 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Proinflammatory signaling in Ewing sarcoma is driven by retroelement activity and counteracted by reverse transcriptase inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Evdokimova+V%22">Evdokimova V</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address: v.evdokimova@gmail.com.<br /><searchLink fieldCode="AU" term="%22Ruzanov+P%22">Ruzanov P</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Gassmann+H%22">Gassmann H</searchLink>; Department of Pediatrics, Children's Cancer Research Center, Kinderklinik München Schwabing and Institute of Pathology, 80804 Munich, Germany; Institute of Pathology, TUM School of Medicine and Health, Technical University of Munich, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hung+M%22">Hung M</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Senff-Ribeiro+A%22">Senff-Ribeiro A</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Khoshgoo+N%22">Khoshgoo N</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Pachva+MC%22">Pachva MC</searchLink>; Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.<br /><searchLink fieldCode="AU" term="%22Ringwalt+EM%22">Ringwalt EM</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Cripe+TP%22">Cripe TP</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; Division of Pediatric Hematology, Oncology, and BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+RD%22">Roberts RD</searchLink>; Center for Childhood Cancer, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; Division of Pediatric Hematology, Oncology, and BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.<br /><searchLink fieldCode="AU" term="%22Sorensen+PH%22">Sorensen PH</searchLink>; Department of Molecular Oncology, British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.<br /><searchLink fieldCode="AU" term="%22Burdach+SEG%22">Burdach SEG</searchLink>; Department of Pediatrics, Children's Cancer Research Center, Kinderklinik München Schwabing and Institute of Pathology, 80804 Munich, Germany; CCC München Comprehensive Cancer Center, DKTK German Cancer Consortium Munich, 80804 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Stein+LD%22">Stein LD</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Radvanyi+L%22">Radvanyi L</searchLink>; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Cancer Research Program, Ottawa Health Research Institute, and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8L6, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A1, Canada. Electronic address: lradvanyi@ohri.ca.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jul 21; Vol. 45 (7), pp. 117708. <i>Date of Electronic Publication: </i>2026 Jul 21.
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        Value: 10.1016/j.celrep.2026.117708
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        Text: English
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