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Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.

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Title: Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
Authors: Grimont A; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Falvo DJ; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Sisso WJ; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA., Santos F; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Chan CW; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Zumbo P; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA., Fall WB; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA., Ferrick K; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Pan G; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Cleveland M; Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Yaron-Barir TM; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA., Osterhoudt A; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA., Meng Y; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA., Zafra MP; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Rendeiro AF; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Hissong E; Department of Pathology, Weill Cornell Medicine, New York, NY 10065, USA., Yantiss RK; Department of Pathology, Weill Cornell Medicine, New York, NY 10065, USA., Betel D; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Magnuson MA; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA., Leach SD; Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; David M. Rubinstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Dartmouth Cancer Center, Dartmouth University, Hanover, NH 03755, USA., Rustgi AK; Herbert Irving Comprehensive Cancer Center, Columbia University School of Medicine, New York, NY 10032, USA., Dow LE; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA., Chandwani R; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; David M. Rubinstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: roc9045@med.cornell.edu.
Source: Developmental cell [Dev Cell] 2026 Jul 21. Date of Electronic Publication: 2026 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Grimont+A%22">Grimont A</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Falvo+DJ%22">Falvo DJ</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Sisso+WJ%22">Sisso WJ</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Santos+F%22">Santos F</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chan+CW%22">Chan CW</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zumbo+P%22">Zumbo P</searchLink>; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Fall+WB%22">Fall WB</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Ferrick+K%22">Ferrick K</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Pan+G%22">Pan G</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Cleveland+M%22">Cleveland M</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Yaron-Barir+TM%22">Yaron-Barir TM</searchLink>; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Osterhoudt+A%22">Osterhoudt A</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Meng+Y%22">Meng Y</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zafra+MP%22">Zafra MP</searchLink>; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Rendeiro+AF%22">Rendeiro AF</searchLink>; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Hissong+E%22">Hissong E</searchLink>; Department of Pathology, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yantiss+RK%22">Yantiss RK</searchLink>; Department of Pathology, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Betel+D%22">Betel D</searchLink>; Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Magnuson+MA%22">Magnuson MA</searchLink>; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Leach+SD%22">Leach SD</searchLink>; Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; David M. Rubinstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Dartmouth Cancer Center, Dartmouth University, Hanover, NH 03755, USA.<br /><searchLink fieldCode="AU" term="%22Rustgi+AK%22">Rustgi AK</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University School of Medicine, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Dow+LE%22">Dow LE</searchLink>; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chandwani+R%22">Chandwani R</searchLink>; Department of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; David M. Rubinstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: roc9045@med.cornell.edu.
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        Value: 10.1016/j.devcel.2026.06.016
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