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SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry.

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Title: SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry.
Authors: Liddicoat BJ; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Balic JJ; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. jesse.balic@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. jesse.balic@petermac.org., Jia W; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Gillespie A; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Das AB; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Scolamiero L; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Bediaga NG; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Chan YC; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., van der Maarel C; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Guirguis AA; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Prest K; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Sinclair OJ; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Talarmain L; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Litchfield C; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Lam EYN; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Hollizeck S; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Horton JR; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kroeger B; Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Wang T; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA, USA., Zappacosta F; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA, USA., Annan RS; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA, USA., Prinjha RK; GlaxoSmithKline R&D Stevenage, Stevenage, UK., Pappalardi MB; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA., Ang CS; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia., Graus MS; The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing, The Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia., Francois M; The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing, The Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia., Harvey KF; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Dawson SJ; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.; The University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia., Cheng X; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dawson MA; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; The University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.
Source: Nature genetics [Nat Genet] 2026 Jul 21. Date of Electronic Publication: 2026 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry.
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  Data: <searchLink fieldCode="AU" term="%22Liddicoat+BJ%22">Liddicoat BJ</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Balic+JJ%22">Balic JJ</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. jesse.balic@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. jesse.balic@petermac.org.<br /><searchLink fieldCode="AU" term="%22Jia+W%22">Jia W</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gillespie+A%22">Gillespie A</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Das+AB%22">Das AB</searchLink>; 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Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zappacosta+F%22">Zappacosta F</searchLink>; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Annan+RS%22">Annan RS</searchLink>; Medicinal Science and Technology, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Prinjha+RK%22">Prinjha RK</searchLink>; GlaxoSmithKline R&D Stevenage, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Pappalardi+MB%22">Pappalardi MB</searchLink>; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22McCabe+MT%22">McCabe MT</searchLink>; Cancer Epigenetics Research Unit, Oncology, GlaxoSmithKline, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ang+CS%22">Ang CS</searchLink>; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Graus+MS%22">Graus MS</searchLink>; The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing, The Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Francois+M%22">Francois M</searchLink>; The David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing, The Centenary Institute, The University of Sydney, Camperdown, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Harvey+KF%22">Harvey KF</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.; Department of Anatomy and Developmental Biology, and Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dawson+SJ%22">Dawson SJ</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.; The University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Cheng+X%22">Cheng X</searchLink>; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dawson+MA%22">Dawson MA</searchLink>; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; The University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.
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