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DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer's disease.

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Title: DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer's disease.
Authors: Wong HY; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; School of Medicine, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Jin C; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Yuen SL; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Yang X; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Gill SS; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Xu J; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Lai KPE; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Fu WY; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Gao W; Bayomics Biotechnology Hong Kong Limited, Hong Kong Special Administrative Region, China., Wang X; Shenzhen BayOmics Biotechnology Co., Ltd, Shenzhen, China., Wang J; Bayomics Biotechnology Hong Kong Limited, Hong Kong Special Administrative Region, China., Cao H; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Lv G; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China., Mok KY; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.; School of Medicine, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China., Tian R; State Key Laboratory of Medical Proteomics and Shenzhen Key Laboratory of Functional Proteomics, Department of Chemistry and Research Center for Chemical Biology and Omics Analysis, School of Science and Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, 518055, China., Fu AKY; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, China., Chen H; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. jhc@ust.hk.; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. jhc@ust.hk.; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. jhc@ust.hk.; HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute, Futian, Shenzhen, China. jhc@ust.hk., Ip NY; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. boip@ust.hk.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China. boip@ust.hk.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China. boip@ust.hk.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, China. boip@ust.hk.; School of Medicine, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. boip@ust.hk.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jul 21. Date of Electronic Publication: 2026 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Wong+HY%22">Wong HY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; School of Medicine, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Jin+C%22">Jin C</searchLink>; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Yuen+SL%22">Yuen SL</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Gill+SS%22">Gill SS</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Lai+KPE%22">Lai KPE</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Fu+WY%22">Fu WY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Gao+W%22">Gao W</searchLink>; Bayomics Biotechnology Hong Kong Limited, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Shenzhen BayOmics Biotechnology Co., Ltd, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Bayomics Biotechnology Hong Kong Limited, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Cao+H%22">Cao H</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Lv+G%22">Lv G</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Mok+KY%22">Mok KY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.; School of Medicine, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Tian+R%22">Tian R</searchLink>; State Key Laboratory of Medical Proteomics and Shenzhen Key Laboratory of Functional Proteomics, Department of Chemistry and Research Center for Chemical Biology and Omics Analysis, School of Science and Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, 518055, China.<br /><searchLink fieldCode="AU" term="%22Fu+AKY%22">Fu AKY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. jhc@ust.hk.; Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. jhc@ust.hk.; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. jhc@ust.hk.; HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute, Futian, Shenzhen, China. jhc@ust.hk.<br /><searchLink fieldCode="AU" term="%22Ip+NY%22">Ip NY</searchLink>; Division of Life Science, State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. boip@ust.hk.; InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science Park, Hong Kong Special Administrative Region, China. boip@ust.hk.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development; Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China. boip@ust.hk.; SIAT-HKUST Joint Laboratory for Brain Science, Shenzhen, Guangdong, China. boip@ust.hk.; School of Medicine, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China. boip@ust.hk.
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