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Early increase in apparent diffusion coefficient predicts favorable response to Dordaviprone (ONC201) therapy in H3K27M-mutant diffuse midline glioma.

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Title: Early increase in apparent diffusion coefficient predicts favorable response to Dordaviprone (ONC201) therapy in H3K27M-mutant diffuse midline glioma.
Authors: Lau BC; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.; Pediatric Neuro-Oncology Program, UPMC, Pittsburgh, PA, USA., Ajaero DP; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Hoff BA; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA., Pearson A; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Sajjakulnukit P; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Wadden J; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Adam T; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Ji S; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Green AL; Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado Anschutz School of Medicine, Children's Hospital Colorado, Aurora, CO, USA., Nabavizadeh A; Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Cao Y; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Aryal M; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Upadhyaya S; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Franson A; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA., Galban S; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA., Venneti S; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA., Federowicz B; xCures, Inc., Oakland, CA, USA., Shapiro MA; xCures, Inc., Oakland, CA, USA., Stuhlmiller TJ; xCures, Inc., Oakland, CA, USA., Lyssiotis C; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Galban CJ; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA., Parmar HA; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA., Ibrahim M; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA., Koschmann C; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Source: Neuro-oncology [Neuro Oncol] 2026 Jul 21. Date of Electronic Publication: 2026 Jul 21.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early increase in apparent diffusion coefficient predicts favorable response to Dordaviprone (ONC201) therapy in H3K27M-mutant diffuse midline glioma.
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  Data: <searchLink fieldCode="AU" term="%22Lau+BC%22">Lau BC</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.; Pediatric Neuro-Oncology Program, UPMC, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ajaero+DP%22">Ajaero DP</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Hoff+BA%22">Hoff BA</searchLink>; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pearson+A%22">Pearson A</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sajjakulnukit+P%22">Sajjakulnukit P</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Wadden+J%22">Wadden J</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Adam+T%22">Adam T</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ji+S%22">Ji S</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Green+AL%22">Green AL</searchLink>; Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado Anschutz School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Nabavizadeh+A%22">Nabavizadeh A</searchLink>; Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Aryal+M%22">Aryal M</searchLink>; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Upadhyaya+S%22">Upadhyaya S</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Franson+A%22">Franson A</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Galban+S%22">Galban S</searchLink>; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Venneti+S%22">Venneti S</searchLink>; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Federowicz+B%22">Federowicz B</searchLink>; xCures, Inc., Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+MA%22">Shapiro MA</searchLink>; xCures, Inc., Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stuhlmiller+TJ%22">Stuhlmiller TJ</searchLink>; xCures, Inc., Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lyssiotis+C%22">Lyssiotis C</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Galban+CJ%22">Galban CJ</searchLink>; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Parmar+HA%22">Parmar HA</searchLink>; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ibrahim+M%22">Ibrahim M</searchLink>; Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Koschmann+C%22">Koschmann C</searchLink>; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
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  Data: <searchLink fieldCode="JN" term="%22100887420%22">Neuro-oncology</searchLink> [Neuro Oncol] 2026 Jul 21. <i>Date of Electronic Publication: </i>2026 Jul 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100887420 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-5866 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215228517%22">15228517 </searchLink><i>NLM ISO Abbreviation: </i>Neuro Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/neuonc/noag164
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        Text: English
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              Text: 2026 Jul 21
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