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Polygenic risk score and risk of drug-induced liver injury after initiating antiretroviral therapy in people living with HIV.

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Title: Polygenic risk score and risk of drug-induced liver injury after initiating antiretroviral therapy in people living with HIV.
Authors: Cindi Z; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Cardone KM; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Bradford Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Hall MA; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Kim H; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Daar ES; Department of Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Gulick R; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Riddler SA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Vujkovic M; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tsao PS; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Sinxadi P; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; SAMRC/UCT Platform for Pharmacogenomics Research and Translation, South African Medical Research Council, Cape Town, South Africa., Haas DW; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Internal Medicine, Meharry Medical College, Nashville, TN, USA., Ritchie MD; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA.; Division of Biomedical Informatics and AI, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Corporate Authors: VA Million Veteran Program
Source: Pharmacogenomics [Pharmacogenomics] 2026 Jul 22, pp. 1-11. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100897350 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8042 (Electronic) Linking ISSN: 14622416 NLM ISO Abbreviation: Pharmacogenomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Cindi+Z%22">Cindi Z</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cardone+KM%22">Cardone KM</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bradford+Y%22">Bradford Y</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hall+MA%22">Hall MA</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Daar+ES%22">Daar ES</searchLink>; Department of Medicine, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gulick+R%22">Gulick R</searchLink>; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Riddler+SA%22">Riddler SA</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vujkovic+M%22">Vujkovic M</searchLink>; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+KM%22">Chang KM</searchLink>; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tsao+PS%22">Tsao PS</searchLink>; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sinxadi+P%22">Sinxadi P</searchLink>; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.; SAMRC/UCT Platform for Pharmacogenomics Research and Translation, South African Medical Research Council, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Haas+DW%22">Haas DW</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Internal Medicine, Meharry Medical College, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ritchie+MD%22">Ritchie MD</searchLink>; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA.; Division of Biomedical Informatics and AI, Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
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