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A kinetically inert platinum antitumor agent overcomes mutant p53-driven chemoresistance via oxidative stress-mediated DNA damage.

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Title: A kinetically inert platinum antitumor agent overcomes mutant p53-driven chemoresistance via oxidative stress-mediated DNA damage.
Authors: Chakraborty S; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India., Shenoy PS; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India., Nath S; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India., Panda TR; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India., Bhat A; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.; Department of Biology, Indian Institute of Science Education and Research, Tirupati, Andhra Pradesh, 517619, India., Sakpal A; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India., Mehrotra M; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India., Singh P; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India., Patra M; Laboratory of Medicinal Chemistry and Cell Biology, Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Navy Nagar, 400005, Mumbai, India., Ray P; Imaging Cell Signaling & Therapeutics Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, 410210, India. pray@actrec.gov.in.; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400094, India. pray@actrec.gov.in.
Source: Medical oncology (Northwood, London, England) [Med Oncol] 2026 Jul 22; Vol. 43 (9). Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-131X
DOI:10.1007/s12032-026-03348-w