Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing.

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Title: Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing.
Authors: Cheng S; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China. chengshi1013@gzhmu.edu.cn., Qi Y; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China., Ya J; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China., Xia L; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China., Zhang W; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China., Xiong Q; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China., Liu Q; Biotherapy Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. liuqli3@mail.sysu.edu.cn., Zhang J; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China. JiaxingZhang1997@163.com., Song Y; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China. songyulong@gzhmu.edu.cn.
Source: Advanced biotechnology [Adv Biotechnol (Singap)] 2026 Jul 22; Vol. 4 (3). Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Singapore Country of Publication: Singapore NLM ID: 9918821788106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2948-2801 (Electronic) Linking ISSN: 29482801 NLM ISO Abbreviation: Adv Biotechnol (Singap) Subsets: PubMed not MEDLINE
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  Data: Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Cheng+S%22">Cheng S</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China. chengshi1013@gzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Qi+Y%22">Qi Y</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ya+J%22">Ya J</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xia+L%22">Xia L</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xiong+Q%22">Xiong Q</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Biotherapy Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. liuqli3@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China. JiaxingZhang1997@163.com.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; The Affiliated Panyu Central Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, GMU-GIBH Joint School of Life Sciences, Guangdong Provincial Key Laboratory of Protein Modification and Disease, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Diseases, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People's Republic of China. songyulong@gzhmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229918821788106676%22">Advanced biotechnology</searchLink> [Adv Biotechnol (Singap)] 2026 Jul 22; Vol. 4 (3). <i>Date of Electronic Publication: </i>2026 Jul 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature+Singapore%22">Springer Nature Singapore </searchLink><i>Country of Publication: </i>Singapore <i>NLM ID: </i>9918821788106676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2948-2801 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2229482801%22">29482801 </searchLink><i>NLM ISO Abbreviation: </i>Adv Biotechnol (Singap) <i>Subsets: </i>PubMed not MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s44307-026-00123-w
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: Short-read RNA-seq yields lower estimates of A-to-I RNA editing levels than long-read cDNA sequencing.
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            NameFull: Cheng S
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            NameFull: Qi Y
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            – D: 22
              M: 07
              Text: 2026 Jul 22
              Type: published
              Y: 2026
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