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Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial.

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Title: Mechanical Thrombectomy in Ischemic Stroke With a Medium or Distal Arterial Occlusion: The DISCOUNT Randomized Clinical Trial.
Authors: Clarençon F; AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.; GRC NoVA, Sorbonne Université, Paris, France., Bala F; AP-HP, Department of Neuroradiology, Tours University Hospital, Tours, France., Baptiste A; Sorbonne Université, Hôpital Pitié-Salpêtrière, Unité de recherche clinique, Paris, France., Pasi M; Department of Vascular Neurology, Tours University Hospital, Tours, France., Marnat G; Department of Neuroradiology, Bordeaux University Hospital, Bordeaux, France., Sibon I; Department of Vascular Neurology, Bordeaux University Hospital, Bordeaux, France., Gory B; Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254, CHRU-Nancy, Université de Lorraine, Nancy, France., Richard S; Department of Neurology, INSERM U1116, Stroke Unit, CHRU-Nancy, Université de Lorraine, Nancy, France., Pop R; Department of Neuroradiology, Strasbourg University Hospital, Strasbourg, France., Wolff V; Department of Vascular Neurology, Strasbourg University Hospital, UR3072, CRBS, University of Strasbourg, Strasbourg, France., Fauché C; Department of Neuroradiology, Poitiers University Hospital, Poitiers, France., Lamy M; Department of Vascular Neurology, Poitiers University Hospital, Poitiers, France., Costalat V; Department of Neuroradiology, Montpellier University Hospital, Montpellier, France., Arquizan C; Department of Vascular Neurology, Montpellier University Hospital, Montpellier, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France., Rodriguez-Régent C; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.; Department of Neuroradiology, GHU Paris Psychiatrie et Neurosciences, Paris, France., Turc G; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.; Department of Vascular Neurology, GHU Paris Psychiatrie et Neurosciences, Paris, France.; Université Paris Cité, Paris, France., Cognard C; Department of Neuroradiology, Toulouse University Hospital, Toulouse, France., Fontaine L; Department of Vascular Neurology, Toulouse University Hospital, Toulouse, France., Di Maria F; Department of Neuroradiology, Foch Hospital, Suresnes, France., Lapergue B; Department of Vascular Neurology, Foch Hospital, Suresnes, France., Bricout N; Department of Neuroradiology, Lille University Hospital, Lille, France., Henon H; Department of Vascular Neurology, Lille University Hospital, Lille, France., Tuilier T; Department of Neuroradiology, Henri-Mondor Hospital, Créteil, France., Wittwer A; Department of Vascular Neurology, Henri-Mondor Hospital, Créteil, France., Alexandre PL; Department of Neuroradiology, Nantes University Hospital, Nantes, France., De Gaalon S; Department of Vascular Neurology, Nantes University Hospital, Nantes, France., Spelle L; Department of Interventional Neuroradiology, Kremlin-Bicêtre Hospital, Kremlin-Bicêtre, France., Denier C; Department of Vascular Neurology, Kremlin-Bicêtre Hospital, Kremlin-Bicêtre, France., Chabert E; Department of Neuroradiology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Ferrier A; Department of Vascular Neurology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France., Rouchaud A; Department of Interventional Neuroradiology, Limoges University Hospital, Limoges, France., Macian-Montoro F; Department of Neurology, Limoges University Hospital, Limoges, France., Soize S; Department of Neuroradiology, Reims University Hospital, Reims, France., Moulin S; Department of Vascular Neurology, Reims University Hospital, Reims, France., Boisseau W; Department of Neuroradiology, Fondation A de Rothschild, Paris, France., Sabben C; Department of Vascular Neurology, Fondation A de Rothschild, Paris, France., Barbier C; Department of Neuroradiology, Caen University Hospital, Caen, France., Boulanger M; Department of Vascular Neurology, Caen University Hospital, Caen, France., Eker OF; Department of Neuroradiology, Lyon University Hospital, Lyon, France., Cho TH; Department of Vascular Neurology, Lyon University Hospital, Lyon, France., Gentric JC; Department of Neuroradiology, Brest University Hospital, Brest, France., Timsit S; Department of Vascular Neurology, Brest University Hospital, Brest, France., Labeyrie MA; Department of Neuroradiology, Lariboisière Hospital, Paris, France., Reiner P; Department of Vascular Neurology, Lariboisière Hospital, Paris, France., Pico F; Department of Vascular Neurology, Versailles Hospital, Versailles, France., Durand-Zaleski I; Université de Paris, CRESS, INSERM, INRA, URCEco, AP-HP, Hôpital de l'Hôtel Dieu., Alamowitch S; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.; Department of Vascular Neurology, Pitié-Salpêtrière Hospital, Paris, France., Dechartres A; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département de Santé Publique, Paris, France.
Corporate Authors: DISCOUNT Investigators
Source: JAMA [JAMA] 2026 Jul 22. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Clarençon+F%22">Clarençon F</searchLink>; AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Department of Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.; GRC NoVA, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bala+F%22">Bala F</searchLink>; AP-HP, Department of Neuroradiology, Tours University Hospital, Tours, France.<br /><searchLink fieldCode="AU" term="%22Baptiste+A%22">Baptiste A</searchLink>; Sorbonne Université, Hôpital Pitié-Salpêtrière, Unité de recherche clinique, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pasi+M%22">Pasi M</searchLink>; Department of Vascular Neurology, Tours University Hospital, Tours, France.<br /><searchLink fieldCode="AU" term="%22Marnat+G%22">Marnat G</searchLink>; Department of Neuroradiology, Bordeaux University Hospital, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Sibon+I%22">Sibon I</searchLink>; Department of Vascular Neurology, Bordeaux University Hospital, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Gory+B%22">Gory B</searchLink>; Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254, CHRU-Nancy, Université de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Richard+S%22">Richard S</searchLink>; Department of Neurology, INSERM U1116, Stroke Unit, CHRU-Nancy, Université de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Pop+R%22">Pop R</searchLink>; Department of Neuroradiology, Strasbourg University Hospital, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Wolff+V%22">Wolff V</searchLink>; Department of Vascular Neurology, Strasbourg University Hospital, UR3072, CRBS, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Fauché+C%22">Fauché C</searchLink>; Department of Neuroradiology, Poitiers University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Lamy+M%22">Lamy M</searchLink>; Department of Vascular Neurology, Poitiers University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Costalat+V%22">Costalat V</searchLink>; Department of Neuroradiology, Montpellier University Hospital, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Arquizan+C%22">Arquizan C</searchLink>; Department of Vascular Neurology, Montpellier University Hospital, Montpellier, France.; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Régent+C%22">Rodriguez-Régent C</searchLink>; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.; Department of Neuroradiology, GHU Paris Psychiatrie et Neurosciences, Paris, France.<br /><searchLink fieldCode="AU" term="%22Turc+G%22">Turc G</searchLink>; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.; Department of Vascular Neurology, GHU Paris Psychiatrie et Neurosciences, Paris, France.; Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cognard+C%22">Cognard C</searchLink>; Department of Neuroradiology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Fontaine+L%22">Fontaine L</searchLink>; Department of Vascular Neurology, Toulouse University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Di+Maria+F%22">Di Maria F</searchLink>; Department of Neuroradiology, Foch Hospital, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Lapergue+B%22">Lapergue B</searchLink>; Department of Vascular Neurology, Foch Hospital, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Bricout+N%22">Bricout N</searchLink>; Department of Neuroradiology, Lille University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Henon+H%22">Henon H</searchLink>; Department of Vascular Neurology, Lille University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Tuilier+T%22">Tuilier T</searchLink>; Department of Neuroradiology, Henri-Mondor Hospital, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Wittwer+A%22">Wittwer A</searchLink>; Department of Vascular Neurology, Henri-Mondor Hospital, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Alexandre+PL%22">Alexandre PL</searchLink>; Department of Neuroradiology, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22De+Gaalon+S%22">De Gaalon S</searchLink>; Department of Vascular Neurology, Nantes University Hospital, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Spelle+L%22">Spelle L</searchLink>; Department of Interventional Neuroradiology, Kremlin-Bicêtre Hospital, Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Denier+C%22">Denier C</searchLink>; Department of Vascular Neurology, Kremlin-Bicêtre Hospital, Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Chabert+E%22">Chabert E</searchLink>; Department of Neuroradiology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Ferrier+A%22">Ferrier A</searchLink>; Department of Vascular Neurology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Rouchaud+A%22">Rouchaud A</searchLink>; 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Department of Vascular Neurology, Caen University Hospital, Caen, France.<br /><searchLink fieldCode="AU" term="%22Eker+OF%22">Eker OF</searchLink>; Department of Neuroradiology, Lyon University Hospital, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Cho+TH%22">Cho TH</searchLink>; Department of Vascular Neurology, Lyon University Hospital, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Gentric+JC%22">Gentric JC</searchLink>; Department of Neuroradiology, Brest University Hospital, Brest, France.<br /><searchLink fieldCode="AU" term="%22Timsit+S%22">Timsit S</searchLink>; Department of Vascular Neurology, Brest University Hospital, Brest, France.<br /><searchLink fieldCode="AU" term="%22Labeyrie+MA%22">Labeyrie MA</searchLink>; Department of Neuroradiology, Lariboisière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Reiner+P%22">Reiner P</searchLink>; Department of Vascular Neurology, Lariboisière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Pico+F%22">Pico F</searchLink>; Department of Vascular Neurology, Versailles Hospital, Versailles, France.<br /><searchLink fieldCode="AU" term="%22Durand-Zaleski+I%22">Durand-Zaleski I</searchLink>; Université de Paris, CRESS, INSERM, INRA, URCEco, AP-HP, Hôpital de l'Hôtel Dieu.<br /><searchLink fieldCode="AU" term="%22Alamowitch+S%22">Alamowitch S</searchLink>; Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Paris, France.; Department of Vascular Neurology, Pitié-Salpêtrière Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dechartres+A%22">Dechartres A</searchLink>; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département de Santé Publique, Paris, France.
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